Assessment and consequences of the constant-volume attribute of the four-chambered heart

被引:62
作者
Bowman, AW
Kovács, SJ
机构
[1] Washington Univ, Sch Med, Cardiovasc Biophys Lab, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Div Cardiovasc, Cardiovasc MR Labs, St Louis, MO 63110 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2003年 / 285卷 / 05期
关键词
cardiac magnetic resonance imaging; mathematical modeling; diastasis; pericardial motion;
D O I
10.1152/ajpheart.00249.2003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The constant-volume hypothesis regarding the four-chambered heart states that total pericardial volume remains invariant throughout the cardiac cycle. Previous canine studies have indicated that the pericardial volume remains constant within 5%; however, this hypothesis has not been validated in humans using state-of-the-art technology. The constant-volume hypothesis has several predictable functional consequences, including a relationship between atrial ejection fraction and chamber equilibrium volumes. Using cardiac magnetic resonance (MR) imaging (MRI), we measured the extent to which the constant-volume attribute of the heart is valid, and we tested the accuracy of the predicted relationship between atrial ejection fraction and chamber equilibrium volumes. Eleven normal volunteers and one volunteer with congenital absence of the pericardium were imaged using a 1.5-T MR scanner. A short-axis cine-loop stack covering the entire heart was acquired. The cardiac cycle was divided into 20 intervals. For each slice and interval, pericardial volumes were measured. The slices were stacked and summed, and total pericardial volume as a function of time was determined for each subject. In the normal subjects, chamber volumes at ventricular end diastole, end systole, and diastasis were measured. Pericardial volume remained invariant within 5 +/- 1% in normal subjects; maximum variation occurred near end systole. In the subject with congenital absence of the pericardium, total heart volume, defined by the epicardial surface, varied by 12%. The predictions of the relationship between atrial ejection fraction and chamber equilibrium volumes were well fit by MRI data. In normal subjects, the four-chambered heart is a constant-volume pump within 5 +/- 1%, and constant- volume-based modeling accurately predicts previously unreported physiological relationships.
引用
收藏
页码:H2027 / H2033
页数:7
相关论文
共 35 条
  • [1] Complex flow patterns in the great vessels: a review
    Bogren, HG
    Buonocore, MH
    [J]. INTERNATIONAL JOURNAL OF CARDIAC IMAGING, 1999, 15 (02): : 105 - 113
  • [2] Cine MR angiography of the heart with segmented true fast imaging with steady-state precession
    Carr, JC
    Simonetti, O
    Bundy, J
    Li, DB
    Pereles, S
    Finn, JP
    [J]. RADIOLOGY, 2001, 219 (03) : 828 - 834
  • [3] The wall-thinning to transmitral flow-velocity relation:: Derivation with in vivo validation
    Cook, D
    Sessoms, M
    Kovács, SJ
    [J]. ULTRASOUND IN MEDICINE AND BIOLOGY, 2002, 28 (06) : 745 - 755
  • [4] MAGNETIC-RESONANCE-IMAGING OF CONSTANT TOTAL HEART-VOLUME AND CENTER-OF-MASS IN PATIENTS WITH FUNCTIONAL SINGLE VENTRICLE BEFORE AND AFTER STAGED FONTAN PROCEDURE
    FOGEL, MA
    WEINBERG, PM
    FELLOWS, KE
    HOFFMAN, EA
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1993, 72 (18) : 1435 - 1443
  • [5] Technical advances in multi-slice spiral CT
    Fuchs, T
    Kachelriess, M
    Kalender, WA
    [J]. EUROPEAN JOURNAL OF RADIOLOGY, 2000, 36 (02) : 69 - 73
  • [6] Three dimensional flow in the human left atrium
    Fyrenius, A
    Wigström, L
    Ebbers, T
    Karlsson, M
    Engvall, J
    Bolger, AF
    [J]. HEART, 2001, 86 (04) : 448 - 455
  • [7] Movements of the base of the ventricle and the relative constancy of the cardiac volume
    Hamilton, WF
    Rompf, JH
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1932, 102 (03): : 559 - 565
  • [8] HOFFMAN E, 1987, J AM COLL CARDIOL, V9, pA38
  • [9] HOFFMAN EA, 1991, IMAGING, MEASUREMENTS AND ANALYSIS OF THE HEART, P3
  • [10] HOFFMAN EA, 1993, ADV EXP MED BIOL, V346, P347