Cell size control - New evidence for a general mechanism

被引：21

作者：

Grebien, F

Dolznig, H

Beug, H

Mullner, EW

机构：

[1] Med Univ Vienna, Vienna Bioctr, Max F Perutz Labs, Div Mol Biol,Dept Med Biochem,Univ Dept, A-1030 Vienna, Austria

[2] Inst Mol Pathol, A-1030 Vienna, Austria

来源：

CELL CYCLE | 2005年 / 4卷 / 03期

基金：

奥地利科学基金会;

关键词：

cell size regulation; chicken erythroblasts; elutriation; re-cultivation; aphidicolin; signal transduction and protein synthesis; v-ErbB; stem cell factor; erythropoietin;

D O I：

10.4161/cc.4.3.1523

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Continuously proliferating cells have to precisely double their size during each cycle to maintain constant volumes. Time and again, this fact raised questions on the existence of an active cell size control mechanism in eukaryotic cells, which would prevent delayed or premature cell division at inadequate mass. We addressed this open issue by recapitulating in animal cells several long-standing experiments which had identified such a mechanism in yeast.

引用

页码：418 / 421

页数：4

共 35 条

[1] A cell sizer network involving Cln3 and Far 1 controls entrance into S phase in the mitotic cycle of budding yeast [J].

Alberghina, L ;

Rossi, RL ;

Querin, L ;

Wanke, V ;

Vanoni, M .

JOURNAL OF CELL BIOLOGY, 2004, 167 (03) :433-443

[2] CELL GROWTH AND DIVISION .4. DETERMINATION OF VOLUME GROWTH RATE AND DIVISION PROBABILITY [J].

ANDERSON, EC ;

BELL, GI ;

PETERSEN, DF ;

TOBEY, RA .

BIOPHYSICAL JOURNAL, 1969, 9 (02) :246-&

[3]

BROOKS RF, CELL CYCLE, V35, P81

[4] Control and maintenance of mammalian cell size: Response [J].

Conlon, I ;

Raff, M .

BMC CELL BIOLOGY, 2004, 5 (1)

[5]

Conlon Ian, 2003, J Biol, V2, P7, DOI 10.1186/1475-4924-2-7

[6] Extracellular control of cell size [J].

Conlon, IJ ;

Dunn, GA ;

Mudge, AW ;

Raff, MC .

NATURE CELL BIOLOGY, 2001, 3 (10) :918-921

[7] Control and maintenance of mammalian cell size [J].

Cooper, S .

BMC CELL BIOLOGY, 2004, 5 (1)

[8]

DOLZNIG H, 1995, CELL GROWTH DIFFER, V6, P1341

[9] Evidence for a size-sensing mechanism in animal cells [J].

Dolznig, H ;

Grebien, F ;

Sauer, T ;

Beug, H ;

Müllner, EW .

NATURE CELL BIOLOGY, 2004, 6 (09) :899-U95

[10] Establishment of normal, terminally differentiating mouse erythroid progenitors:: molecular characterization by cDNA arrays [J].

Dolznig, H ;

Boulmé, F ;

Stangl, K ;

Deiner, EM ;

Mikulits, W ;

Beug, H ;

Müllner, EW .

FASEB JOURNAL, 2001, 15 (06) :1442-+

← 1 2 3 4 →