An overview of Cdk1-controlled targets and processes

被引：316

作者：

Enserink, Jorrit M. ^{[1
,2
]}

Kolodner, Richard D. ^{[3
,4
,5
]}

机构：

[1] Oslo Univ Hosp, Dept Mol Biol, Inst Med Microbiol, N-0027 Oslo, Norway

[2] Oslo Univ Hosp, Ctr Mol Biol & Neurosci, N-0027 Oslo, Norway

[3] Univ Calif San Diego, Ludwig Inst Canc Res, Dept Med, Sch Med, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Ludwig Inst Canc Res, Dept Cellular & Mol Med, Sch Med, La Jolla, CA 92093 USA

[5] Univ Calif San Diego, Ctr Canc, Sch Med, La Jolla, CA 92093 USA

来源：

CELL DIVISION | 2010年 / 5卷

关键词：

CYCLIN-DEPENDENT KINASE; DNA-DAMAGE CHECKPOINT; YEAST-CELL-CYCLE; SPINDLE POLE BODY; ANAPHASE-PROMOTING COMPLEX; CDK-ACTIVATING KINASE; GTP-BINDING PROTEIN; STRAND-BREAK REPAIR; S-PHASE CYCLINS; B-TYPE CYCLINS;

D O I：

10.1186/1747-1028-5-11

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the model organism S. cerevisiae. Research performed during the past decade has significantly improved our understanding of the molecular machinery of the cell cycle. Approximately 75 targets of Cdk1 have been identified that control critical cell cycle events, such as DNA replication and segregation, transcriptional programs and cell morphogenesis. In this review we discuss currently known targets of Cdk1 in the budding yeast S. cerevisiae and highlight the role of Cdk1 in several crucial processes including maintenance of genome stability.

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页数：41

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