Enantioselective synthesis of the ester side chain of homoharringtonine

被引：27

作者：

Keller, L ^{[1
]}

Dumas, F ^{[1
]}

d'Angelo, J ^{[1
]}

机构：

[1] Univ Paris Sud, UA CNRS, Ctr Etud Pharmaceut, F-92296 Chatenay Malabry, France

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 10期

关键词：

antitumor compounds; asymmetric synthesis; cyanohydrins; ozonolysis; ring transformations;

D O I：

10.1016/S0040-4039(01)00086-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Michael adduct 6 was converted in ten steps with an overall yield of 5.7% into the methyl ester derivative of the side chain of homoharringtonine, (R)-17. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1911 / 1913

页数：3

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