Antifungal combinations against Candida albicans biofilms in vitro

被引：68

作者：

Bachmann, SP

Ramage, G

VandeWalle, K

Patterson, TF

Wickes, BL

López-Ribot, JL

机构：

[1] Univ Texas, Hlth Sci Ctr, S Texas Ctr Biol Med, Dept Med,Div Infect Dis, San Antonio, TX 78245 USA

[2] Univ Texas, Hlth Sci Ctr, Dept Microbiol, San Antonio, TX 78245 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 11期

关键词：

D O I：

10.1128/AAC.47.11.3657-3659.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Candida biofilms display increased resistance to most antifungal agents. We have evaluated the efficacy of combinations of fluconazole (FLC), amphotericin B, and caspofungin (CSP) against Candida albicans biofilms in vitro. Indifference was observed for all the combinations of paired antifungal agents when a checkerboard titration method was used. Time-kill experiments revealed an antagonistic effect of high FLC doses with CSP.

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页码：3657 / 3659

页数：3

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