Mast cell signal transduction from the high-affinity IgE receptor

被引：219

作者：

Siraganian, RP ^{[1
]}

机构：

[1] NIDCR, Oral Infect & Immun, Receptors & Signal Transduct Sect, NIH, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2003年 / 15卷 / 06期

关键词：

D O I：

10.1016/j.coi.2003.09.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antigen-mediated aggregation of IgE bound to its high-affinity receptor on mast cells or basophils initiates a complex series of biochemical events, resulting in the release of mediators that cause allergic inflammation and anaphylactic reactions. Recent progress has defined the molecular pathways that are involved in stimulating these cells and has shown the importance of protein tyrosine kinases in the subsequent reactions. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules.

引用

页码：639 / 646

页数：8

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