Redox-active metal complexes for imaging hypoxic tissues: structure-activity relationships in copper(II) bis(thiosemicarbazone) complexes

被引：148

作者：

Dearling, JLJ

Lewis, JS

McCarthy, DW

Welch, MJ

Blower, PJ ^{[1
]}

机构：

[1] Univ Kent, Dept Biosci, Canterbury CT2 7NJ, Kent, England

[2] Washington Univ, Sch Med, Edward Mallinckrodt Inst Radiol, St Louis, MO 63110 USA

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 22期

关键词：

D O I：

10.1039/a805957h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reduction potential and lipophilicity of the copper(II) bis(thiosemicarbazone) complexes can be independently controlled by alkylation in the diketone backbone and the N-termini of the ligand, allowing optimisation of radiopharmaceuticals strongly selective for hypoxic tissues.

引用

页码：2531 / 2532

页数：2

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