Diversity of inorganic arsenite biotransformation

被引：38

作者：

Healy, SM

Wildfang, E

Zakharyan, RA

Aposhian, HV ^{[1
]}

机构：

[1] Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA

[2] Univ Arizona, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA

[3] Univ Arizona, Dept Pharmacol, Tucson, AZ 85721 USA

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 1999年 / 68卷 / 03期

关键词：

arsenic; biotransformation; diversity;

D O I：

10.1007/BF02783907

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biotransformation of inorganic arsenic in mammals is catalyzed by three serial enzyme activities: arsenate reductase, arsenite methyltransferase, and monomethylarsonate methyltransferase. Our laboratory has purified and characterized these enzymes in order to understand the mechanisms and elucidate the variations of the responses to arsenate/arsenite challenge. Our results indicate a marked deficiency and diversity of these enzyme activities in various animal species.

引用

页码：249 / 266

页数：18

共 65 条

[1] ARSENIC INDUCES AND ENHANCES RAT HEPATIC METALLOTHIONEIN PRODUCTION INVIVO [J].