共 41 条
In vitro and in vivo activation induces BAFF and APRIL expression in B cells
被引:106
作者:

Chu, Van Trung
论文数: 0 引用数: 0
h-index: 0
机构: Deutsches Rheuma ForschungsZentrum, Berlin, Germany

Enghard, Philipp
论文数: 0 引用数: 0
h-index: 0
机构: Deutsches Rheuma ForschungsZentrum, Berlin, Germany

Riemekasten, Gabriela
论文数: 0 引用数: 0
h-index: 0
机构: Deutsches Rheuma ForschungsZentrum, Berlin, Germany

Berek, Claudia
论文数: 0 引用数: 0
h-index: 0
机构: Deutsches Rheuma ForschungsZentrum, Berlin, Germany
机构:
[1] Deutsches Rheuma ForschungsZentrum, Berlin, Germany
[2] Charite, Dept Rheumatol & Clin Immunol, Berlin, Germany
关键词:
D O I:
10.4049/jimmunol.179.9.5947
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
B cell-activating factor (BA.FF) and a proliferation-inducing ligand (APRIL) play key roles in peripheral B cell survival, maturation, and differentiation. BAFF and APRIL are produced by a variety of cell types such as macrophages/monocytes and dendritic cells. Our analysis shows that BAFF mRNA is also expressed in all B cell subsets isolated from bone marrow, spleen, and peritoneal cavity of BALB/c mice. APRIL expression is restricted to early stages of B cell development in the bone marrow and the peritoneal B1 subset. Stimulation of B2 and B1 cells with LPS or CpG-oligodeoxynucleotides induced MyD88-dependent plasma cell differentiation and intracellular expression of BAFF and APRIL. Furthermore, activation of B cells up-regulated membrane expression of BAFF. The finding that in vitro activation of B cells is inhibited by the antagonist transmembrane activator and calcium modulator ligand interactor Ig, indicates that BAFF and/or APRIL are released into the culture supernatants. It shows that B cell survival, proliferation, and differentiation are supported by an autocrine pathway. In vivo activation of B cells with a T-dependent Ag- induced BAFF expression in germinal center B cells. In (NZB X NZW)F, mice with established autoimmune disease, marginal zone, germinal center B cells, as well as splenic plasma cells expressed high levels of BAFF. In (NZB X NZW)F-1 mice, the continuous activation of B cells and thus overexpression of BAFF and APRIL may contribute to the development of autoimmune disease.
引用
收藏
页码:5947 / 5957
页数:11
相关论文
共 41 条
[1]
The molecular architecture of the TNF superfamily
[J].
Bodmer, JL
;
Schneider, P
;
Tschopp, J
.
TRENDS IN BIOCHEMICAL SCIENCES,
2002, 27 (01)
:19-26

Bodmer, JL
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Lausanne, Inst Biochem, CH-1066 Epalinges, Switzerland Univ Lausanne, Inst Biochem, CH-1066 Epalinges, Switzerland

Schneider, P
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Lausanne, Inst Biochem, CH-1066 Epalinges, Switzerland Univ Lausanne, Inst Biochem, CH-1066 Epalinges, Switzerland

Tschopp, J
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Lausanne, Inst Biochem, CH-1066 Epalinges, Switzerland Univ Lausanne, Inst Biochem, CH-1066 Epalinges, Switzerland
[2]
Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL
[J].
Chiu, April
;
Xu, Weifeng
;
He, Bing
;
Dillon, Stacey R.
;
Gross, Jane A.
;
Sievers, Eric
;
Qiao, Xugang
;
Santini, Paul
;
Hyjek, Elizabeth
;
Lee, Joong-Won
;
Cesarman, Ethel
;
Chadburn, Amy
;
Knowles, Daniel M.
;
Cerutti, Andrea
.
BLOOD,
2007, 109 (02)
:729-739

Chiu, April
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA

Xu, Weifeng
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA

He, Bing
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA

Dillon, Stacey R.
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA

Gross, Jane A.
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA

Sievers, Eric
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA

Qiao, Xugang
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA

Santini, Paul
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA

Hyjek, Elizabeth
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA

Lee, Joong-Won
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA

Cesarman, Ethel
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA

Chadburn, Amy
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA

Knowles, Daniel M.
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA

Cerutti, Andrea
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA
[3]
Macrophage- and dendritic cell-dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF
[J].
Craxton, A
;
Magaletti, D
;
Ryan, EJ
;
Clark, EA
.
BLOOD,
2003, 101 (11)
:4464-4471

Craxton, A
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Microbiol, Seattle, WA 98195 USA Univ Washington, Dept Microbiol, Seattle, WA 98195 USA

Magaletti, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Microbiol, Seattle, WA 98195 USA

Ryan, EJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Microbiol, Seattle, WA 98195 USA

Clark, EA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Microbiol, Seattle, WA 98195 USA
[4]
Homeostatic niche specification among naive and activated B cells: A growing role for the BLyS family of receptors and ligands
[J].
Crowley, JE
;
Treml, LS
;
Stadanlick, JE
;
Carpenter, E
;
Cancro, MP
.
SEMINARS IN IMMUNOLOGY,
2005, 17 (03)
:193-199

Crowley, JE
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

Treml, LS
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

Stadanlick, JE
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

Carpenter, E
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

Cancro, MP
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
[5]
Selectivity of BAFF/BLyS and APRIL for binding to the TNF family receptors BAFFR/BR3 and BCMA
[J].
Day, ES
;
Cachero, TG
;
Qian, F
;
Sun, Y
;
Wen, D
;
Pelletier, M
;
Hsu, YM
;
Whitty, A
.
BIOCHEMISTRY,
2005, 44 (06)
:1919-1931

Day, ES
论文数: 0 引用数: 0
h-index: 0
机构:
Biogen Idec Inc, Dept Drug Discovery, Cambridge Ctr 14, Cambridge, MA 02142 USA Biogen Idec Inc, Dept Drug Discovery, Cambridge Ctr 14, Cambridge, MA 02142 USA

Cachero, TG
论文数: 0 引用数: 0
h-index: 0
机构:
Biogen Idec Inc, Dept Drug Discovery, Cambridge Ctr 14, Cambridge, MA 02142 USA Biogen Idec Inc, Dept Drug Discovery, Cambridge Ctr 14, Cambridge, MA 02142 USA

Qian, F
论文数: 0 引用数: 0
h-index: 0
机构:
Biogen Idec Inc, Dept Drug Discovery, Cambridge Ctr 14, Cambridge, MA 02142 USA Biogen Idec Inc, Dept Drug Discovery, Cambridge Ctr 14, Cambridge, MA 02142 USA

Sun, Y
论文数: 0 引用数: 0
h-index: 0
机构:
Biogen Idec Inc, Dept Drug Discovery, Cambridge Ctr 14, Cambridge, MA 02142 USA Biogen Idec Inc, Dept Drug Discovery, Cambridge Ctr 14, Cambridge, MA 02142 USA

Wen, D
论文数: 0 引用数: 0
h-index: 0
机构:
Biogen Idec Inc, Dept Drug Discovery, Cambridge Ctr 14, Cambridge, MA 02142 USA Biogen Idec Inc, Dept Drug Discovery, Cambridge Ctr 14, Cambridge, MA 02142 USA

Pelletier, M
论文数: 0 引用数: 0
h-index: 0
机构:
Biogen Idec Inc, Dept Drug Discovery, Cambridge Ctr 14, Cambridge, MA 02142 USA Biogen Idec Inc, Dept Drug Discovery, Cambridge Ctr 14, Cambridge, MA 02142 USA

Hsu, YM
论文数: 0 引用数: 0
h-index: 0
机构:
Biogen Idec Inc, Dept Drug Discovery, Cambridge Ctr 14, Cambridge, MA 02142 USA Biogen Idec Inc, Dept Drug Discovery, Cambridge Ctr 14, Cambridge, MA 02142 USA

Whitty, A
论文数: 0 引用数: 0
h-index: 0
机构:
Biogen Idec Inc, Dept Drug Discovery, Cambridge Ctr 14, Cambridge, MA 02142 USA Biogen Idec Inc, Dept Drug Discovery, Cambridge Ctr 14, Cambridge, MA 02142 USA
[6]
Normal B cell homeostasis requires B cell activation factor production by radiation-resistant cells
[J].
Gorelik, L
;
Gilbride, K
;
Dobles, M
;
Kalled, SL
;
Zandman, D
;
Scott, ML
.
JOURNAL OF EXPERIMENTAL MEDICINE,
2003, 198 (06)
:937-945

Gorelik, L
论文数: 0 引用数: 0
h-index: 0
机构:
Biogen Inc, Cambridge, MA 02142 USA Biogen Inc, Cambridge, MA 02142 USA

Gilbride, K
论文数: 0 引用数: 0
h-index: 0
机构:
Biogen Inc, Cambridge, MA 02142 USA Biogen Inc, Cambridge, MA 02142 USA

Dobles, M
论文数: 0 引用数: 0
h-index: 0
机构:
Biogen Inc, Cambridge, MA 02142 USA Biogen Inc, Cambridge, MA 02142 USA

Kalled, SL
论文数: 0 引用数: 0
h-index: 0
机构:
Biogen Inc, Cambridge, MA 02142 USA Biogen Inc, Cambridge, MA 02142 USA

Zandman, D
论文数: 0 引用数: 0
h-index: 0
机构:
Biogen Inc, Cambridge, MA 02142 USA Biogen Inc, Cambridge, MA 02142 USA

Scott, ML
论文数: 0 引用数: 0
h-index: 0
机构:
Biogen Inc, Cambridge, MA 02142 USA Biogen Inc, Cambridge, MA 02142 USA
[7]
Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjogren's syndrome
[J].
Groom, J
;
Kalled, SL
;
Cutler, AH
;
Olson, C
;
Woodcock, SA
;
Schneider, P
;
Tschopp, J
;
Cachero, TG
;
Batten, M
;
Wheway, J
;
Mauri, D
;
Cavill, D
;
Gordon, TP
;
Mackay, CR
;
Mackay, F
.
JOURNAL OF CLINICAL INVESTIGATION,
2002, 109 (01)
:59-68

Groom, J
论文数: 0 引用数: 0
h-index: 0
机构: Garvan Inst Med Res, Dept Arthrit & Inflammat, Darlinghurst, NSW 2010, Australia

Kalled, SL
论文数: 0 引用数: 0
h-index: 0
机构: Garvan Inst Med Res, Dept Arthrit & Inflammat, Darlinghurst, NSW 2010, Australia

Cutler, AH
论文数: 0 引用数: 0
h-index: 0
机构: Garvan Inst Med Res, Dept Arthrit & Inflammat, Darlinghurst, NSW 2010, Australia

Olson, C
论文数: 0 引用数: 0
h-index: 0
机构: Garvan Inst Med Res, Dept Arthrit & Inflammat, Darlinghurst, NSW 2010, Australia

Woodcock, SA
论文数: 0 引用数: 0
h-index: 0
机构: Garvan Inst Med Res, Dept Arthrit & Inflammat, Darlinghurst, NSW 2010, Australia

Schneider, P
论文数: 0 引用数: 0
h-index: 0
机构: Garvan Inst Med Res, Dept Arthrit & Inflammat, Darlinghurst, NSW 2010, Australia

Tschopp, J
论文数: 0 引用数: 0
h-index: 0
机构: Garvan Inst Med Res, Dept Arthrit & Inflammat, Darlinghurst, NSW 2010, Australia

Cachero, TG
论文数: 0 引用数: 0
h-index: 0
机构: Garvan Inst Med Res, Dept Arthrit & Inflammat, Darlinghurst, NSW 2010, Australia

Batten, M
论文数: 0 引用数: 0
h-index: 0
机构: Garvan Inst Med Res, Dept Arthrit & Inflammat, Darlinghurst, NSW 2010, Australia

Wheway, J
论文数: 0 引用数: 0
h-index: 0
机构: Garvan Inst Med Res, Dept Arthrit & Inflammat, Darlinghurst, NSW 2010, Australia

Mauri, D
论文数: 0 引用数: 0
h-index: 0
机构: Garvan Inst Med Res, Dept Arthrit & Inflammat, Darlinghurst, NSW 2010, Australia

Cavill, D
论文数: 0 引用数: 0
h-index: 0
机构: Garvan Inst Med Res, Dept Arthrit & Inflammat, Darlinghurst, NSW 2010, Australia

Gordon, TP
论文数: 0 引用数: 0
h-index: 0
机构: Garvan Inst Med Res, Dept Arthrit & Inflammat, Darlinghurst, NSW 2010, Australia

Mackay, CR
论文数: 0 引用数: 0
h-index: 0
机构: Garvan Inst Med Res, Dept Arthrit & Inflammat, Darlinghurst, NSW 2010, Australia

Mackay, F
论文数: 0 引用数: 0
h-index: 0
机构: Garvan Inst Med Res, Dept Arthrit & Inflammat, Darlinghurst, NSW 2010, Australia
[8]
BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex
[J].
Hase, H
;
Kanno, Y
;
Kojima, M
;
Hasegawa, K
;
Sakurai, D
;
Kojima, H
;
Tsuchiya, N
;
Tokunaga, K
;
Masawa, N
;
Azuma, M
;
Okumura, K
;
Kobata, T
.
BLOOD,
2004, 103 (06)
:2257-2265

Hase, H
论文数: 0 引用数: 0
h-index: 0
机构: Dokkyo Univ, Sch Med, Inst Med Sci, Div Immunol, Mibu, Tochigi 3210293, Japan

Kanno, Y
论文数: 0 引用数: 0
h-index: 0
机构: Dokkyo Univ, Sch Med, Inst Med Sci, Div Immunol, Mibu, Tochigi 3210293, Japan

Kojima, M
论文数: 0 引用数: 0
h-index: 0
机构: Dokkyo Univ, Sch Med, Inst Med Sci, Div Immunol, Mibu, Tochigi 3210293, Japan

Hasegawa, K
论文数: 0 引用数: 0
h-index: 0
机构: Dokkyo Univ, Sch Med, Inst Med Sci, Div Immunol, Mibu, Tochigi 3210293, Japan

Sakurai, D
论文数: 0 引用数: 0
h-index: 0
机构: Dokkyo Univ, Sch Med, Inst Med Sci, Div Immunol, Mibu, Tochigi 3210293, Japan

Kojima, H
论文数: 0 引用数: 0
h-index: 0
机构: Dokkyo Univ, Sch Med, Inst Med Sci, Div Immunol, Mibu, Tochigi 3210293, Japan

Tsuchiya, N
论文数: 0 引用数: 0
h-index: 0
机构: Dokkyo Univ, Sch Med, Inst Med Sci, Div Immunol, Mibu, Tochigi 3210293, Japan

Tokunaga, K
论文数: 0 引用数: 0
h-index: 0
机构: Dokkyo Univ, Sch Med, Inst Med Sci, Div Immunol, Mibu, Tochigi 3210293, Japan

Masawa, N
论文数: 0 引用数: 0
h-index: 0
机构: Dokkyo Univ, Sch Med, Inst Med Sci, Div Immunol, Mibu, Tochigi 3210293, Japan

Azuma, M
论文数: 0 引用数: 0
h-index: 0
机构: Dokkyo Univ, Sch Med, Inst Med Sci, Div Immunol, Mibu, Tochigi 3210293, Japan

Okumura, K
论文数: 0 引用数: 0
h-index: 0
机构: Dokkyo Univ, Sch Med, Inst Med Sci, Div Immunol, Mibu, Tochigi 3210293, Japan

Kobata, T
论文数: 0 引用数: 0
h-index: 0
机构: Dokkyo Univ, Sch Med, Inst Med Sci, Div Immunol, Mibu, Tochigi 3210293, Japan
[9]
Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLyS and APRIL
[J].
He, B
;
Chadburn, A
;
Jou, E
;
Schattner, EJ
;
Knowles, DM
;
Cerutti, A
.
JOURNAL OF IMMUNOLOGY,
2004, 172 (05)
:3268-3279

He, B
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA

Chadburn, A
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA

Jou, E
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA

Schattner, EJ
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA

Knowles, DM
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA

Cerutti, A
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA
[10]
BAFF production by antigen-presenting cells provides T cell co-stimulation
[J].
Huard, B
;
Arlettaz, L
;
Ambrose, C
;
Kindler, V
;
Mauri, D
;
Roosnek, E
;
Tschopp, J
;
Schneider, P
;
French, LE
.
INTERNATIONAL IMMUNOLOGY,
2004, 16 (03)
:467-475

Huard, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med Ctr, Dept Dermatol, CH-7211 Geneva 4, Switzerland

Arlettaz, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med Ctr, Dept Dermatol, CH-7211 Geneva 4, Switzerland

Ambrose, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med Ctr, Dept Dermatol, CH-7211 Geneva 4, Switzerland

Kindler, V
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med Ctr, Dept Dermatol, CH-7211 Geneva 4, Switzerland

Mauri, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med Ctr, Dept Dermatol, CH-7211 Geneva 4, Switzerland

Roosnek, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med Ctr, Dept Dermatol, CH-7211 Geneva 4, Switzerland

Tschopp, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med Ctr, Dept Dermatol, CH-7211 Geneva 4, Switzerland

Schneider, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med Ctr, Dept Dermatol, CH-7211 Geneva 4, Switzerland

French, LE
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med Ctr, Dept Dermatol, CH-7211 Geneva 4, Switzerland