Arabidopsis cryptochrome 1 interacts with SPA1 to suppress COP1 activity in response to blue light

被引：319

作者：

Liu, Bin ^{[1
,2
]}

Zuo, Zecheng ^{[1
,3
]}

Liu, Hongtao ^{[1
]}

Liu, Xuanming ^{[3
]}

Lin, Chentao ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90095 USA

[2] Chinese Acad Agr Sci, Inst Crop Sci, Beijing 100081, Peoples R China

[3] Hunan Univ, Coll Life Sci, Changsha 410082, Hunan, Peoples R China

来源：

GENES & DEVELOPMENT | 2011年 / 25卷 / 10期

基金：

美国国家卫生研究院;

关键词：

blue-light receptor; cryptochrome; E3 ubiquitin ligase; protein degradation; photomorphogenesis; SIGNAL-TRANSDUCTION; PHOTOMORPHOGENESIS; PHOTORECEPTORS; PHYTOCHROME; PROTEINS; CRY2; HY5; EXPRESSION; REPRESSION; PHOTOLYASE;

D O I：

10.1101/gad.2025011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Plant photoreceptors mediate light suppression of the E3 ubiquitin ligase COP1 (CONSTITUTIVE PHOTOMORPHOGENIC 1) to affect gene expression and photomorphogenesis. However, how photoreceptors mediate light regulation of COP1 activity remains unknown. We report here that Arabidopsis blue-light receptor cryptochrome 1 (CRY1) undergoes blue-light-dependent interaction with the COP1-interacting protein SPA1 (SUPPRESSOR OF PHYTOCHROME A). We further show that the CRY1-SPA1 interaction suppresses the SPA1-COP1 interaction and COP1-dependent degradation of the transcription factor HY5. These results are consistent with a hypothesis that photoexcited CRY1 interacts with SPA1 to modulate COP1 activity and plant development.

引用

页码：1029 / 1034

页数：6

共 34 条

[1] HY4 GENE OF A-THALIANA ENCODES A PROTEIN WITH CHARACTERISTICS OF A BLUE-LIGHT PHOTORECEPTOR [J].

AHMAD, M ;

CASHMORE, AR .

NATURE, 1993, 366 (6451) :162-166

[2] REGULATORY HIERARCHY OF PHOTOMORPHOGENIC LOCI - ALLELE-SPECIFIC AND LIGHT-DEPENDENT INTERACTION BETWEEN THE HY5 AND COP1 LOCI [J].

ANG, LH ;

DENG, XW .

PLANT CELL, 1994, 6 (05) :613-628

[3] Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana [J].

Brautigam, CA ;

Smith, BS ;

Ma, ZQ ;

Palnitkar, M ;

Tomchick, DR ;

Machius, M ;

Deisenhofer, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (33) :12142-12147

[4] The cryptochrome family of photoreceptors [J].

Cashmore, AR .

PLANT CELL AND ENVIRONMENT, 1997, 20 (06) :764-767

[5] COP1 - A REGULATORY LOCUS INVOLVED IN LIGHT-CONTROLLED DEVELOPMENT AND GENE-EXPRESSION IN ARABIDOPSIS [J].

DENG, XW ;

CASPAR, T ;

QUAIL, PH .

GENES & DEVELOPMENT, 1991, 5 (07) :1172-1182

[6] Functional and expression analysis of Arabidopsis SPA genes during seedling photomorphogenesis and adult growth [J].

Fittinghoff, Kirsten ;

Laubinger, Sascha ;

Nixdorf, Markus ;

Fackendahl, Petra ;

Baumgardt, Rosalinde-Louise ;

Batschauer, Alfred ;

Hoecker, Ute .

PLANT JOURNAL, 2006, 47 (04) :577-590

[7] Regulations of flowering time by Arabidopsis photoreceptors [J].

Guo, HW ;

Yang, WY ;

Mockler, TC ;

Lin, CT .

SCIENCE, 1998, 279 (5355) :1360-1363

[8]

Hoecker U, 2001, J BIOL CHEM, V276, P38173

[9] SPA1, a WD-repeat protein specific to phytochrome A signal transduction [J].

Hoecker, U ;

Tepperman, JM ;

Quail, PH .

SCIENCE, 1999, 284 (5413) :496-499

[10] Light-regulated transcriptional networks in higher plants [J].

Jiao, Yuling ;

Lau, On Sun ;

Deng, Xing Wang .

NATURE REVIEWS GENETICS, 2007, 8 (03) :217-230

← 1 2 3 4 →