Bacterial DNA as immune cell activator

被引：109

作者：

Lipford, GB ^{[1
]}

Heeg, K ^{[1
]}

Wagner, H ^{[1
]}

机构：

[1] Inst Med Microbiol Immunol & Hyg, D-81675 Munich, Germany

来源：

TRENDS IN MICROBIOLOGY | 1998年 / 6卷 / 12期

关键词：

D O I：

10.1016/S0966-842X(98)01408-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pattern recognition receptors of the innate and adaptive immune systems apparently recognize unmethylated CpG motifs of bacterial DNA. Cells of the innate immune system are activated directly by CpG motifs, and the resulting response dictates a Th1 bias to the developing adaptive immune response. Interestingly, antigen receptor occupancy of cells of the adaptive immune system augments their responsiveness to CpG motifs, suggesting that co-stimulatory mechanisms are operative.

引用

页码：496 / 500

页数：7

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