The transcription factors SOX9 and SOX10 are vitiligo autoantigens in autoimmune polyendocrine syndrome type I

被引:83
作者
Hedstrand, H [1 ]
Ekwall, O
Olsson, MJ
Landgren, E
Kemp, EH
Weetman, AP
Perheentupa, J
Husebye, E
Gustafsson, J
Betterle, C
Kämpe, O
Rorsman, F
机构
[1] Univ Uppsala Hosp, Dept Med Sci, SE-75185 Uppsala, Sweden
[2] No Gen Hosp, Dept Clin Sci, Sheffield S5 7AU, S Yorkshire, England
[3] Univ Helsinki, Hosp Children & Adolescents, FIN-00014 Helsinki, Finland
[4] Haukeland Hosp, Inst Med, Div Endocrinol, NO-5021 Bergen, Norway
[5] Univ Uppsala Hosp, Dept Womens & Childrens Hlth, S-75185 Uppsala, Sweden
[6] Univ Padua, Inst Med Semeiot, I-35128 Padua, Italy
关键词
D O I
10.1074/jbc.M102391200
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Vitiligo is common in the hereditary disorder autoimmune polyendocrine syndrome type I (APS I). Patients with APS I are known to have high titer autoantibodies directed against various tissue-specific antigens. Using sera from APS I patients for immunoscreening of a cDNA library from human scalp, we identified the transcription factors SOX9 and SOX10 as novel autoantigens related to this syndrome. Immunoreactivity against SOX9 was found in 14 (15%) and against SOX10 in 20 (22%) of the 91 APS I sera studied. All patients reacting with SOX9 displayed reactivity against SOX10, suggesting shared epitopes. Among the 19 patients with vitiligo, 12 (63%) were positive for SOX10 (p < 0.0001). Furthermore, three of 93 sera from patients with vitiligo, unrelated to APS I showed strong reactivity against SOX10 which may indicate a more general role of SOX10 as an autoantigen in vitiligo.
引用
收藏
页码:35390 / 35395
页数:6
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