Tailoring the active site of chemzymes by using a chemogenetic-optimization procedure: Towards substrate-specific artificial hydrogenases based on the biotin-avidin technology

被引：83

作者：

Klein, G ^{[1
]}

Humbert, N ^{[1
]}

Gradinaru, J ^{[1
]}

Ivanova, A ^{[1
]}

Gilardoni, F ^{[1
]}

Rusbandi, UE ^{[1
]}

Ward, TR ^{[1
]}

机构：

[1] Univ Neuchatel, Inst Chem, CH-2007 Neuchatel, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 47期

关键词：

asymmetric catalysis; combinatorial chemistry; hydrogenation; metalloenzymes; mutagenesis;

D O I：

10.1002/anie.200502000

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The combination of chemical- with genetic-optimization strategies (i.e. chemogenetic) allows the production of artificial hydrogenases based on the biotin-avidin technology. In the spirit of enzymes, second-coordination-sphere interactions between the host protein (streptavidin) and the substrate (an olefin) allow fine-tuning of the selectivity to produce either R or S hydrogenation products. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7764 / 7767

页数：4

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