ret/PTC and BRAF act as distinct molecular, time-dependant triggers in a sporadic Irish cohort of papillary thyroid carcinoma

被引：36

作者：

Smyth, P ^{[1
]}

Finn, S ^{[1
]}

Cahill, S ^{[1
]}

O'Regan, E ^{[1
]}

Flavin, R ^{[1
]}

O'Leary, JJ ^{[1
]}

Sheils, O ^{[1
]}

机构：

[1] Trinity Coll Dublin, Dept Histopathol, Dublin, Ireland

来源：

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY | 2005年 / 13卷 / 01期

关键词：

BRAF; ret/PTC; papillary thyroid carcinoma; temporal trends;

D O I：

10.1177/106689690501300101

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The purpose of this study was to assess BRAF mutation rates in various thyroid tissues and to investigate if concomitant mutations with ret/PTC activation occurred in inflammatory and neoplastic lesions. To this end, we developed a novel Taqman(R) based screening assay for the common T1799A BRAF mutation. Heterozygous T1799A mutations were detected in 13 of 34 (44%) papillary thyroid carcinomas (PTCs) tested. No such mutations were detected in the other tissue types tested. Concomitant presence of both oncogenes was reported in 5 of the 34 PTCs. A significant temporal trend was observed, with ret/PTC chimera detected for the most part before 1997 and BRAF mutations being more prevalent after 1997. The results suggest that some environmental/etiological agent(s) may have influenced the pathobiology of thyroid tumor development, among the population examined, over time.

引用

页码：1 / 8

页数：8

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