Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity

被引:334
作者
Strachan, CJ
Taday, PF
Newnham, DA
Gordon, KC
Zeitler, JA
Pepper, M
Rades, T
机构
[1] Univ Otago, Sch Pharm, Dunedin, New Zealand
[2] TeraView Ltd, Cambridge CB4 0WG, England
[3] Univ Otago, Dept Chem, Dunedin, New Zealand
[4] Univ Cambridge, Cavendish Lab, Cambridge CB3 0HE, England
关键词
partial least squares; polymorphism; crystallinity; amorphous; infrared spectroscopy; carbamazepine; enalapril maleate; indomethacin; fenoprofen calcium;
D O I
10.1002/jps.20281
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Terahertz pulsed spectroscopy (TPS) is a new technique that is capable of eliciting rich information when investigating pharmaceutical materials. In solids, it probes long-range crystalline lattice vibrations and low energy torsion and hydrogen bonding vibrations. These properties make TPS potentially an ideal tool to investigate crystallinity and polymorphism. In this study four drugs with different solid-state properties were analyzed using TPS and levels of polymorphism and crystallinity were quantified. Carbamazepine and enalapril maleate polymorphs, amorphous, and crystalline indomethacin, and thermotropic liquid crystalline and crystalline fenoprofen calcium mixtures were quantified using partial least-squares analysis. Root-mean-squared errors of cross validation as low as 0.349% and limits of detection as low as approximately 1% were obtained, demonstrating that TPS is an analytical technique of potential in quantifying solid-state properties of pharmaceutical compounds. (c) 2005 Wiley-Liss, Inc. and the American Pharmacists Association.
引用
收藏
页码:837 / 846
页数:10
相关论文
共 59 条
[1]   Crystal nucleation and growth of indomethacin polymorphs from the amorphous state [J].
Andronis, V ;
Zografi, G .
JOURNAL OF NON-CRYSTALLINE SOLIDS, 2000, 271 (03) :236-248
[2]  
[Anonymous], 1996, ICH Q2B
[3]   Qualitative and quantitative study of polymorphic forms in drug formulations by near infrared FT-Raman spectroscopy [J].
Auer, ME ;
Griesser, UJ ;
Sawatzki, J .
JOURNAL OF MOLECULAR STRUCTURE, 2003, 661 :307-317
[4]   Terahertz spectroscopy [J].
Beard, MC ;
Turner, GM ;
Schmuttenmaer, CA .
JOURNAL OF PHYSICAL CHEMISTRY B, 2002, 106 (29) :7146-7159
[5]  
BEEBE KR, 1998, CHEMOMETRICS PRACTIC, P348
[6]  
BERNSTEIN J, 2002, POLYMORPHISM MOL CRY, P410
[7]  
BIANCO M, 1998, ANALYST, V123, pR135
[8]  
Brittain H. G., 1995, PHYS CHARACTERIZATIO
[9]   Spectral methods for the characterization of polymorphs and solvates [J].
Brittain, HG .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1997, 86 (04) :405-412
[10]  
BRITTAIN HG, 2000, POLYMORPHISM PHARM S