Immunogenicity, safety and tolerability of monovalent 2009 pandemic influenza A/H1N1 MF59-adjuvanted vaccine in patients with β-thalassemia major

被引：15

作者：

Esposito, Susanna ^{[1
]}

D'Angelo, Emanuela ^{[1
]}

Daleno, Cristina ^{[1
]}

Peia, Francesco ^{[1
]}

Scala, Alessia ^{[1
]}

Serra, Domenico ^{[1
]}

Mirra, Nadia ^{[1
]}

Galeone, Carlotta ^{[2
]}

Principi, Nicola ^{[1
]}

机构：

[1] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Maternal & Pediat Sci, I-20122 Milan, Italy

[2] Ist Ric Farmacol Mario Negri, Dept Epidemiol, Milan, Italy

来源：

VACCINE | 2010年 / 28卷 / 50期

关键词：

Pandemic influenza A/H1N1 influenza vaccine; Pandemic A/H1N1 influenza virus; MF59; Adjuvants; Vaccination; Children; ANTIBODY-RESPONSES; CHILDREN; VIRUS;

D O I：

10.1016/j.vaccine.2010.09.058

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In order to evaluate the immunogenicity, safety, and tolerability of monovalent 2009 pandemic influenza A/H1N1 MF59-adjuvanted vaccine in patients with beta-thalassemia major, 31 subjects (19 males; mean age 17.8 +/- 8.7 years) with beta-thalassemia major and 28 age- and gender-matched healthy controls were enrolled. Four weeks after vaccination, seroconversion rates were about 80% and seroprotection rates 100% in both groups. Three months after vaccination, most of the subjects remained seroconverted and the seroprotection rates were 93.5% among the patients and 100% among the controls. Safety and tolerability were also very good, with no differences between the groups. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：7825 / 7828

页数：4

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