Synthesis of the azatricyclic core of FR901483 by bridgehead vinylation via an anti-Bredt iminium ion

被引：58

作者：

Suzuki, H ^{[1
]}

Yamazaki, N ^{[1
]}

Kibayashi, C ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Hachioji, Tokyo 1920392, Japan

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 16期

关键词：

bridgehead chemistry; metathesis; oxazolidines; vinylation;

D O I：

10.1016/S0040-4039(01)00345-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed an alternative route to the azatricyclic core skeleton of FR901483 based on vinylation at the bridgehead position of 2-azabicyclo[3.3.1]nonane via an anti-Bredt iminium ion using vinylaluminum reagents. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3013 / 3015

页数：3

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