Intrathecal clonidine for refractory detrusor hyperreflexia in spinal cord injured patients: A preliminary report

被引：19

作者：

Denys, P ^{[1
]}

Chartier-Kastler, E ^{[1
]}

Azouvi, P ^{[1
]}

Remy-Neris, O ^{[1
]}

Bussel, B ^{[1
]}

机构：

[1] Raymond Poincare Hosp, Dept Neurol Rehabil, Garches, France

来源：

JOURNAL OF UROLOGY | 1998年 / 160卷 / 06期

关键词：

urodynamics; clonidine; spinal cord; bladder;

D O I：

10.1016/S0022-5347(01)62260-2

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: We assessed the urodynamic effect of various doses of intrathecal clonidine on refractory detrusor hyperreflexia in spinal cord injured patients. Materials and Methods: Doses of 15, 30 or 45 mu g. intrathecal clonidine or placebo were given to 5 chronic complete spinal cord injured patients with detrusor hyperreflexia. Two cystometries were performed before and 5, 30, 60, 90, 120 and 180 minutes after each injection. Results: A statistically significant dose dependent decrease in detrusor hyperreflexia was observed in each patient without significant side effect. Conclusions: Intrathecal clonidine may represent a conservative reversible treatment for detrusor hyperreflexia via a subcutaneous programmable pump, like that used for baclofen, for spasticity. The long-term efficacy needs to be evaluated.

引用

页码：2137 / 2138

页数：2