Alteration of blood hemorheologic properties during cerebral ischemia and reperfusion in rats

The cerebral ischemia and reperfusion rat model was employed in this experiment to study the rheological properties (i.e. viscosity, hematocrit, red blood cell deformability and thixotropic properties) of whole blood. The results of this study show that a significant relation exists between the duration of cerebral ischemia and reperfusion and the viscosity, hematocrit and thixotropic parameters of whole blood, but there is no significant influence on the deformability of RBC. Blood viscosity Values declined gradually throughout the ischemia period, e.g., after 1 h of ischemia, the values of whole blood viscosity under high, middle and low shear rates were 44, 28 and 23 % lower than normal, respectively. Whereas after 1 h of reperfusion, the values of viscosity increased rapidly to values 160, 57 and 41% higher than normal under the high, middle and low levels of shear rate, while the viscosity values after 12h of reperfusion tended to return to normal values. The values of hematocrit H and thixotropic parameter tau (0) and mu also gradually declined with the increase in the duration of ischemia, but increased significantly after 1h of reperfusion. The values of H, tau (0) and mu after 1 h of reperfusion are significantly greater than that in the period of cerebral ischemia, the Value of H, tau (0) is also higher than normal. With the increase in reperfusion time, H, tau (0) gradually returned to normal level, at the same time, mu also decreased. (C) 2001 Elsevier Science Ltd. All rights reserved.