Phosmet induces up-regulation of surface levels of the cellular prion protein

被引：15

作者：

Gordon, I ^{[1
]}

Abdulla, EM ^{[1
]}

Campbell, IC ^{[1
]}

Whatley, SA ^{[1
]}

机构：

[1] Inst Psychiat, Dept Neurosci, London SE5 8AF, England

来源：

NEUROREPORT | 1998年 / 9卷 / 07期

关键词：

BSE; organophosphates; prion diseases; prion protein;

D O I：

10.1097/00001756-199805110-00026

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

CHRONIC (2 day) exposure of human neuroblastoma cells to the organophosphate pesticide phosmet induced a marked concentration-dependent increase in the levels of PrP present on the cell surface as assessed by biotin labelling and immunoprecipitation. Levels of both phospholipase C (PIPLC)-releasable and non-releasable forms of PrP were increased on the plasma membrane. These increases appear to be due to post-transcriptional mechanisms, since PrP mRNA levels as assessed by Northern blotting were unaffected by phosmet treatment. These data raise the possibility that phosmet exposure could increase the susceptibility to the prion agent by altering the levels of accessible PrP. (C) 1998 Rapid Science Ltd.

引用

页码：1391 / 1395

页数：5

共 25 条

[1] BIOCHEMICAL AND PHYSICAL-PROPERTIES OF THE PRION PROTEIN FROM 2 STRAINS OF THE TRANSMISSIBLE MINK ENCEPHALOPATHY AGENT [J].