On-line conversion and determination of aspirin using a flow injection-capillary electrophoresis system

被引：14

作者：

Chen, HL

Fan, LY

Chen, XG ^{[1
]}

Hu, ZD

Zhao, ZF

Hooper, M

机构：

[1] Lanzhou Univ, Dept Chem, Lanzhou 730000, Peoples R China

[2] Monash Univ, Sch Appl Sci, Churchill, Vic 3842, Australia

来源：

JOURNAL OF SEPARATION SCIENCE | 2003年 / 26卷 / 9-10期

关键词：

on-line conversion; flow injection-capillary electrophoresis coupling; acetylsalicylic acid; salicylic acid;

D O I：

10.1002/jssc.200301517

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A novel, rapid, and simple capillary electrophoresis (CE) method has been developed for the determination of aspirin by on-line treatment with alkali. Such on-line reaction with 0.20 mol/L NaOH solution for 2.5 min at 45degreesC automatically and reproducibly converts aspirin into its hydrolysis product salicylic acid. Analysis is carried out in less than 12 min after conversion of aspirin in a flow injection (FI) system coupled to a CE instrument via a split-flow interface cell, and a sampling frequency of 9 h(-1) is achievable. The on-line conversion method has been used to determine aspirin in four commercial pharmaceutical preparations, and the results are satisfactory.

引用

页码：863 / 868

页数：6

共 19 条

[1] On-line ion-exchange preconcentration in a flow injection system coupled to capillary electrophoresis for the direct determination of UV absorbing anions [J].