Using proteomics to identify potential therapeutic targets in platelets

被引：15

作者：

Maguire, FB ^{[1
]}

Foy, M ^{[1
]}

Fitzgerald, DJ ^{[1
]}

机构：

[1] Univ Coll Dublin, Conway Inst, Dept Mol Med, Dublin 4, Ireland

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2005年 / 33卷

关键词：

MS; membrane lipid raft; platelet phosphoproteome; platelet releasate; platelet; proteomics;

D O I：

10.1042/BST0330409

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proteomics has provided powerful new insights into the complex events of the anucleate platelet and has revealed many potential protein targets in the search for suitable agents for thrombotic disease. in the present study, we summarize recent proteomic approaches to analyse specific platelet subproteomes, such as the platelet releasate, the platelet phosphotyrosine proteome and characterization of the proteins associated with membrane lipid rafts.

引用

页码：409 / 412

页数：4

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