Spermatozoa with chromosomal abnormalities may result in a higher rate of recurrent abortion

被引：39

作者：

Giorlandino, C ^{[1
]}

Calugi, G ^{[1
]}

Iaconianni, L ^{[1
]}

Santoro, ML ^{[1
]}

Lippa, A ^{[1
]}

机构：

[1] Artemisia Med Ctr, I-00198 Rome, Italy

来源：

FERTILITY AND STERILITY | 1998年 / 70卷 / 03期

关键词：

abortion; spermatozoa; FISH; percoll;

D O I：

10.1016/S0015-0282(98)00192-7

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To determine whether sperm aneuploidy can lead to abortion. Design: Clinical study. Setting: Couples with reproductive problems evaluated in a private diagnostic laboratory. Patient(s): Two men whose wives had histories of multiple abortions. Intervention(s): Whole and Percoll-processed semen samples were analyzed. Main Outcome Measure(s): The results of fluorescence in situ hybridization. Result(s): Aneuploidy rates in Percoll-processed samples were higher than these found in whole specimens. Aneuploid spermatozoa also displayed greater motility. Conclusion(s): Sperm aneuploidy should be studied before and after Percoll capacitation in all couples with unexplained infertility. (Fertil Steril(R) 1998;70:576-7. (C) 1998 by American Society for Reproductive Medicine.).

引用

页码：576 / 577

页数：2