Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly

被引：417

作者：

Hasegawa, M ^{[1
]}

Smith, MJ ^{[1
]}

Goedert, M ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

来源：

FEBS LETTERS | 1998年 / 437卷 / 03期

基金：

英国医学研究理事会;

关键词：

tau protein; microtubule assembly; frontotemporal dementia; Alzheimer's disease;

D O I：

10.1016/S0014-5793(98)01217-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently exonic and intronic mutations in the gene for microtubule-associated protein tau have been discovered in cases of familial frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), Intronic mutations have been shown to lead to an abnormal preponderance of four-repeat tau isoforms, The effects of the exonic mutations are unknown. We report here that the G272V, P301L, V337M and R406W mutations lead to a marked reduction in the ability of tan to promote microtubule assembly, This partial loss-of-function may be the primary effect of the known missense mutations in tau. (C) 1998 Federation of European Biochemical Societies.

引用

页码：207 / 210

页数：4

共 26 条

[1] STRUCTURE AND NOVEL EXONS OF THE HUMAN-TAU GENE [J].