Intra-cerebellar infusion of NMDA receptor antagonist AP5 disrupts classical eyeblink conditioning in rabbits

被引:17
作者
Chen, GX
Steinmetz, JE [1 ]
机构
[1] Indiana Univ, Program Neural Sci, Bloomington, IN 47405 USA
[2] Indiana Univ, Dept Psychol, Bloomington, IN 47405 USA
关键词
plasticity; learning and memory; interpositus nucleus; cerebellar cortex; response timing;
D O I
10.1016/S0006-8993(00)03005-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Rabbits were infused with AP5, an NMDA receptor antagonist, into the region of the cerebellar interpositus nucleus during classical eyeblink conditioning with a tone conditioned stimulus and an air puff unconditioned stimulus. Acquisition of the conditioned eyeblink response was delayed in rabbits infused with AP5 but the NMDA receptor antagonist had little effect on conditioned responses when these same rabbits were infused a second time after reaching asymptotic responding levels. Some rabbits that received AP5 infusions for the first time after the conditioned response was well learned showed temporary alterations in response timing. These data indicate that NMDA receptor activity is involved in the acquisition of classically conditioned eyeblink response and may also be involved in regulating cellular processes involved in response timing and other aspects of conditioned response execution. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:144 / 156
页数:13
相关论文
共 45 条
[1]   DIFFERENTIAL EXPRESSION OF 5 N-METHYL-D-ASPARTATE RECEPTOR SUBUNIT MESSENGER-RNAS IN THE CEREBELLUM OF DEVELOPING-RATS AND ADULT-RATS [J].
AKAZAWA, C ;
SHIGEMOTO, R ;
BESSHO, Y ;
NAKANISHI, S ;
MIZUNO, N .
JOURNAL OF COMPARATIVE NEUROLOGY, 1994, 347 (01) :150-160
[2]  
ATWELL PJE, 1999, J NEUROSCI, V19, P1
[3]   EXCITATORY SYNAPTIC POTENTIALS IN NEURONS OF THE DEEP NUCLEI IN OLIVOCEREBELLAR SLICE CULTURES [J].
AUDINAT, E ;
GAHWILER, BH ;
KNOPFEL, T .
NEUROSCIENCE, 1992, 49 (04) :903-911
[4]   RESPONSES TO EXCITATORY AMINO-ACIDS OF PURKINJE-CELLS AND NEURONS OF THE DEEP NUCLEI IN CEREBELLAR SLICE CULTURES [J].
AUDINAT, E ;
KNOPFEL, T ;
GAHWILER, BH .
JOURNAL OF PHYSIOLOGY-LONDON, 1990, 430 :297-313
[5]   A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].
BLISS, TVP ;
COLLINGRIDGE, GL .
NATURE, 1993, 361 (6407) :31-39
[6]   Microinjections of anisomycin into the intermediate cerebellum during learning affect the acquisition of classically conditioned responses in the rabbit [J].
Bracha, V ;
Irwin, KB ;
Webster, ML ;
Wunderlich, DA ;
Stachowiak, MK ;
Bloedel, JR .
BRAIN RESEARCH, 1998, 788 (1-2) :169-178
[7]   INTRAAMYGDALA INFUSION OF THE N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST AP5 IMPAIRS ACQUISITION BUT NOT PERFORMANCE OF DISCRIMINATED APPROACH TO AN APPETITIVE CS [J].
BURNS, LH ;
EVERITT, BJ ;
ROBBINS, TW .
BEHAVIORAL AND NEURAL BIOLOGY, 1994, 61 (03) :242-250
[8]   Detailed behavioral analysis of water maze acquisition under APV or CNQX: Contribution of sensorimotor disturbances to drug-induced acquisition deficits [J].
Cain, DP ;
Saucier, D ;
Hall, J ;
Hargreaves, EL ;
Boon, F .
BEHAVIORAL NEUROSCIENCE, 1996, 110 (01) :86-102
[9]   INTRAAMYGDALA INFUSION OF THE N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST AP5 BLOCKS ACQUISITION BUT NOT EXPRESSION OF FEAR-POTENTIATED STARTLE TO AN AUDITORY CONDITIONED-STIMULUS [J].
CAMPEAU, S ;
MISERENDINO, MJD ;
DAVIS, M .
BEHAVIORAL NEUROSCIENCE, 1992, 106 (03) :569-574
[10]   SPATIAL MEMORY AND N-METHYL-D-ASPARTATE RECEPTOR ANTAGONISTS APV AND MK-801 - MEMORY IMPAIRMENTS DEPEND ON FAMILIARITY WITH THE ENVIRONMENT, DRUG DOSE, AND TRAINING DURATION [J].
CARAMANOS, Z ;
SHAPIRO, ML .
BEHAVIORAL NEUROSCIENCE, 1994, 108 (01) :30-43