Developmental age-dependent upregulation of choline acetyltransferase and vesicular acetylcholine transporter mRNA expression in neonatal rat septum by nerve growth factor

被引:35
作者
Tian, XT [1 ]
Sun, XY [1 ]
Suszkiw, JB [1 ]
机构
[1] UNIV CINCINNATI, COLL MED, DEPT CELLULAR & MOLEC PHYSIOL, CINCINNATI, OH 45267 USA
关键词
rat; septum; vesicular acetylcholine transporter; choline acetyltransferase; mRNA; nerve growth factor;
D O I
10.1016/0304-3940(96)12629-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We examined the effect of intraventricular injection of nerve growth factor (NGF) on the choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) mRNA expression in the septa of neonatal rats. Rat pups were injected with 2.5 S NGF or cytochrome-e (control) on postnatal days (PN) 4 and 18, and sacrificed 3 days after injections for analysis of ChAT and VAChT mRNA levels by dot-blot hybridization of total septal RNA. In the NGF-treated pups, the ChAT and VAChT mRNA levels were elevated 3- and 2-fold, respectively, at PN7, and 1.8- and 1.3-fold at PN21. These results indicate that (1) NGF upregulates the expression of both ChAT and VAChT genes, (2) NGF has a greater effect on the expression of ChAT mRNA than VAChT mRNA, and (3) the effect of exogenous NGF on the expression of both genes diminishes with developmental age.
引用
收藏
页码:134 / 136
页数:3
相关论文
共 19 条
[1]   PROMOTER ELEMENTS OF THE RAT CHOLINE-ACETYLTRANSFERASE GENE ALLOWING NERVE GROWTH-FACTOR INDUCIBILITY IN TRANSFECTED PRIMARY CULTURED-CELLS [J].
BEJANIN, S ;
HABERT, E ;
BERRARD, S ;
EDWARDS, JBDM ;
LOEFFLER, JP ;
MALLET, J .
JOURNAL OF NEUROCHEMISTRY, 1992, 58 (04) :1580-1583
[2]  
BEJANIN S, 1994, J BIOL CHEM, V269, P21944
[3]  
BERRARD S, 1995, J NEUROCHEM, V65, P939
[4]   COORDINATED UP-REGULATION OF CHOLINE-ACETYLTRANSFERASE AND VESICULAR ACETYLCHOLINE TRANSPORTER GENE-EXPRESSION BY THE RETINOIC ACID RECEPTOR-ALPHA, CAMP, AND LEUKEMIA INHIBITORY FACTOR CILIARY NEUROTROPHIC FACTOR SIGNALING PATHWAYS IN A MURINE SEPTAL CELL-LINE [J].
BERSE, B ;
BLUSZTAJN, JK .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (38) :22101-22104
[5]   COMPLETE SEQUENCE OF A CDNA-ENCODING AN ACTIVE-RAT CHOLINE-ACETYLTRANSFERASE - A TOOL TO INVESTIGATE THE PLASTICITY OF CHOLINERGIC PHENOTYPE EXPRESSION [J].
BRICE, A ;
BERRARD, S ;
RAYNAUD, B ;
ANSIEAU, S ;
COPPOLA, T ;
WEBER, MJ ;
MALLET, J .
JOURNAL OF NEUROSCIENCE RESEARCH, 1989, 23 (03) :266-273
[6]   CHOLINE-ACETYLTRANSFERASE MESSENGER-RNA EXPRESSION IN DEVELOPING AND ADULT-RAT BRAIN - REGULATION BY NERVE GROWTH-FACTOR [J].
CAVICCHIOLI, L ;
FLANIGAN, TP ;
DICKSON, JG ;
VANTINI, G ;
DALTOSO, R ;
FUSCO, M ;
WALSH, FS ;
LEON, A .
MOLECULAR BRAIN RESEARCH, 1991, 9 (04) :319-325
[7]   P1B15 - A CDNA CLONE OF THE RAT MESSENGER-RNA ENCODING CYCLOPHILIN [J].
DANIELSON, PE ;
FORSSPETTER, S ;
BROW, MA ;
CALAVETTA, L ;
DOUGLASS, J ;
MILNER, RJ ;
SUTCLIFFE, JG .
DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY, 1988, 7 (04) :261-267
[8]   EFFECTS OF NERVE GROWTH-FACTOR ON CHOLINERGIC BRAIN NEURONS [J].
DREYFUS, CF .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1989, 10 (04) :145-149
[9]  
ERICKSON JD, 1994, J BIOL CHEM, V269, P21929
[10]  
GNAHN H, 1983, DEV BRAIN RES, V9, P45, DOI 10.1016/0165-3806(83)90107-4