Filtering the noise of embryonic development

被引:2
作者
Houchmandzadeh, B [1 ]
机构
[1] Spectrometrie Phys Lab, F-38402 St Martin Dheres, France
关键词
D O I
10.1088/0953-8984/17/14/014
中图分类号
O469 [凝聚态物理学];
学科分类号
070205 ;
摘要
Embryonic development is the generation of a multicellular organism from a single cell. During this process, tissues and organs are differentiated and positioned at different parts of the organism. In this paper, we deal with the precision (embryo to embryo variations) of this process by looking at the early development of the fruit fly embryo. We show that precision of the antero-posterior gene expression pattern is hard coded at the very first stages of development. The noise reduction mechanism is extremely robust and resistant to mutations, in contrast to the actual position of the tissues themselves.
引用
收藏
页码:S1245 / S1258
页数:14
相关论文
共 30 条
[1]   DROSOPHILA DEVELOPMENT - MAKING STRIPES INELEGANTLY [J].
AKAM, M .
NATURE, 1989, 341 (6240) :282-283
[2]  
Alberts B., 2002, Molecular Biology of The Cell, V4th
[3]   Cooperative DNA-binding by Bicoid provides a mechanism for threshold-dependent gene activation in the Drosophila embryo [J].
Burz, DS ;
Rivera-Pomar, R ;
Jäckle, H ;
Hanes, SD .
EMBO JOURNAL, 1998, 17 (20) :5998-6009
[4]   DETERMINATION OF SPATIAL DOMAINS OF ZYGOTIC GENE-EXPRESSION IN THE DROSOPHILA EMBRYO BY THE AFFINITY OF BINDING-SITES FOR THE BICOID MORPHOGEN [J].
DRIEVER, W ;
THOMA, G ;
NUSSLEINVOLHARD, C .
NATURE, 1989, 340 (6232) :363-367
[5]   THE BICOID PROTEIN DETERMINES POSITION IN THE DROSOPHILA EMBRYO IN A CONCENTRATION-DEPENDENT MANNER [J].
DRIEVER, W ;
NUSSLEINVOLHARD, C .
CELL, 1988, 54 (01) :95-104
[6]   Robustness of the BMP morphogen gradient in Drosophila embryonic patterning [J].
Eldar, A ;
Dorfman, R ;
Weiss, D ;
Ashe, H ;
Shilo, BZ ;
Barkai, N .
NATURE, 2002, 419 (6904) :304-308
[7]   TRANSLATIONAL REGULATION OF NANOS BY RNA LOCALIZATION [J].
GAVIS, ER ;
LEHMANN, R .
NATURE, 1994, 369 (6478) :315-318
[8]   Establishment of developmental precision and proportions in the early Drosophila embryo [J].
Houchmandzadeh, B ;
Wieschaus, E ;
Leibler, S .
NATURE, 2002, 415 (6873) :798-802
[9]  
HOUCHMANDZADEH B, UNPUB
[10]  
HOWARD KR, 1990, DEVELOPMENT, V110, P1223