The Role of HDAC6 in Cancer

被引：333

作者：

Aldana-Masangkay, Grace I. ^{[1
,2
,3
]}

Sakamoto, Kathleen M. ^{[1
,4
,5
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Div Hematol Oncol, Gwynne Hazen Cherry Mem Labs,Dept Pediat, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, Jonsson Comprehens Canc Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, Calif Nanosyst Inst, Los Angeles, CA 90095 USA

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2011年

基金：

美国国家卫生研究院;

关键词：

2 CATALYTIC DOMAINS; HISTONE DEACETYLASES; CELL MOTILITY; GLUCOCORTICOID-RECEPTOR; TUBULIN ACETYLATION; BREAST-CANCER; IN-VIVO; MICROTUBULES; INHIBITORS; EXPRESSION;

D O I：

10.1155/2011/875824

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Histone deacetylase 6 (HDAC6), a member of the HDAC family whose major substrate is a-tubulin, has become a target for drug development to treat cancer due to its major contribution in oncogenic cell transformation. Overexpression of HDAC6 correlates with tumorigenesis and improved survival; therefore, HDAC6 may be used as a marker for prognosis. Previous work demonstrated that in multiple myeloma cells, inhibition of HDAC6 results in apoptosis. Furthermore, HDAC6 is required for the activation of heat-shock factor 1 (HSF1), an activator of heat-shock protein encoding genes (HSPs) and CYLD, a cylindromatosis tumor suppressor gene. HDAC6 contributes to cancer metastasis since its upregulation increases cell motility in breast cancer MCF-7 cells and its interaction with cortactin regulates motility. HDAC6 also affects transcription and translation by regulating the heat-shock protein 90 (Hsp90) and stress granules (SGs), respectively. This review will discuss the role of HDAC6 in the pathogenesis and treatment of cancer.

引用

页数：10

共 60 条

[1] HDAC6 Regulates Androgen Receptor Hypersensitivity and Nuclear Localization via Modulating Hsp90 Acetylation in Castration-Resistant Prostate Cancer [J].

Ai, Junkui ;

Wang, Yujuan ;

Dar, Javid A. ;

Liu, June ;

Liu, Lingqi ;

Nelson, Joel B. ;

Wang, Zhou .

MOLECULAR ENDOCRINOLOGY, 2009, 23 (12) :1963-1972

[2]

[Anonymous], 2007, BIOL CANC

[3]

[Anonymous], 2004, Molecular Biology of the Cell

[4] Ubiquitin Proteasome System Stress Underlies Synergistic Killing of Ovarian Cancer Cells by Bortezomib and a Novel HDAC6 Inhibitor [J].

Bazzaro, Martina ;

Lin, Zhenhua ;

Santillan, Antonio ;

Lee, Michael K. ;

Wang, Mei-Cheng ;

Chan, Kwun C. ;

Bristow, Robert E. ;

Mazitschek, Ralph ;

Bradner, James ;

Roden, Richard B. S. .

CLINICAL CANCER RESEARCH, 2008, 14 (22) :7340-7347

[5] HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination [J].

Boyault, C. ;

Sadoul, K. ;

Pabion, M. ;

Khochbin, S. .

ONCOGENE, 2007, 26 (37) :5468-5476

[6] HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates [J].

Boyault, Cyril ;

Zhang, Yu ;

Fritah, Sabrina ;

Caron, Cecile ;

Gilquin, Benoit ;

Kwon, So Hee ;

Garrido, Carmen ;

Yao, Tso-Pang ;

Vourc'h, Claire ;

Matthias, Patrick ;

Khochbin, Saadi .

GENES & DEVELOPMENT, 2007, 21 (17) :2172-2181

[7] Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors [J].

Bradbury, C ;

Khanim, F ;

Hayden, R ;

Bunce, CM ;

White, DA ;

Drayson, MT ;

Craddock, C ;

Turner, BM .

LEUKEMIA, 2005, 19 (10) :1751-1759

[8] Cortactin promotes cell motility by enhancing lamellipodial persistence [J].

Bryce, NS ;

Clark, ES ;

Leysath, JL ;

Currie, JD ;

Webb, DJ ;

Weaver, AM .

CURRENT BIOLOGY, 2005, 15 (14) :1276-1285

[9] Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity [J].

Cabrero, J. Roman ;

Serrador, Juan M. ;

Barreiro, Olga ;

Mittelbrunn, Maria ;

Naranjo-Suarez, Salvador ;

Martin-Cofreces, Noa ;

Vicente-Manzanares, Miguel ;

Mazitschek, Ralph ;

Bradner, James E. ;

Avila, Jesus ;

Valenzuela-Fernandez, Agustin ;

Sanchez-Madrid, Francisco .

MOLECULAR BIOLOGY OF THE CELL, 2006, 17 (08) :3435-3445

[10] Histone deacetylase inhibitors: Mechanisms of cell death and promise in combination cancer therapy [J].

Carew, Jennifer S. ;

Giles, Francis J. ;

Nawrocki, Steffan T. .

CANCER LETTERS, 2008, 269 (01) :7-17

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