Mutational status of IgVH genes in B-cell chronic lymphocytic leukemia and prognosis:: Percent mutations or antigen-driven selection?

被引：16

作者：

Bomben, R

Dal Bo, M

Zucchetto, A

Zaina, E

Nanni, P

Sonego, P

Del Poeta, G

Degan, M

Gattei, V

机构：

[1] IRCCS, Clin & Expt Hematol Res Unit, Ctr Riferimento Oncol, Aviano, PN, Italy

[2] Univ Roma Tor Vergata, S Eugenio Hosp, Rome, Italy

来源：

LEUKEMIA | 2005年 / 19卷 / 08期

关键词：

D O I：

10.1038/sj.leu.2403830

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：1490 / 1492

页数：3

共 8 条

[1]

CURRIERI C, 2002, J EXP MED, V196, P629

[2] Analysis of IgVH gene mutations in B cell chronic lymphocytic leukaemia according to antigen-driven selection identifies subgroups with different prognosis and usage of the canonical somatic hypermutation machinery [J].

Degan, M ;

Bomben, R ;

Dal Bo, M ;

Zucchetto, A ;

Nanni, P ;

Rupolo, M ;

Steffan, A ;

Attadia, V ;

Ballerini, PF ;

Damiani, D ;

Pucillo, C ;

Del Poeta, G ;

Colombatti, A ;

Gattei, V .

BRITISH JOURNAL OF HAEMATOLOGY, 2004, 126 (01) :29-42

[3] Analysis of the targeting of the hypermutational machinery and the impact of subsequent selection on the distribution of nucleotide changes in human VHDJH rearrangements [J].

Dorner, T ;

Foster, SJ ;

Brezinschek, HP ;

Lipsky, PE .

IMMUNOLOGICAL REVIEWS, 1998, 162 :161-171

[4] Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene [J].

Ghia, P ;

Stamatopoulos, K ;

Belessi, C ;

Moreno, C ;

Stella, S ;

Guida, G ;

Michel, A ;

Crespo, M ;

Laoutaris, N ;

Montserrat, E ;

Anagnostopoulos, A ;

Dighiero, G ;

Fassas, A ;

Caligaris-Cappio, F ;

Davi, F .

BLOOD, 2005, 105 (04) :1678-1685

[5] VH mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia [J].

Kröber, A ;

Seiler, T ;

Benner, A ;

Bullinger, L ;

Brückle, E ;

Lichter, P ;

Döhner, H ;

Stilgenbauer, S .

BLOOD, 2002, 100 (04) :1410-1416

[6]

LANE BS, 2005, ANAL VH GENE SEQUENC

[7] Prognosis at diagnosis: integrating molecular biologic insights into clinical practice for patients with CLL [J].

Shanafelt, TD ;

Geyer, SM ;

Kay, NE .

BLOOD, 2004, 103 (04) :1202-1210

[8] VH3-21 gene usage in chronic lymphocytic leukemia -: Characterization of a new subgroup with distinct molecular features and poor survival [J].

Tobin, G ;

Söderberg, O ;

Thunberg, U ;

Rosenquist, R .

LEUKEMIA & LYMPHOMA, 2004, 45 (02) :221-228

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