Erythropoiesis, EPO, macrophages, and bone

被引：51

作者：

Eggold, Joshua T. ^{[1
,2
]}

Rankin, Erinn B. ^{[1
,2
,3
]}

机构：

[1] Stanford Univ, Dept Radiat Oncol, Sch Med, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Canc Biol Program, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Dept Obstet & Gynecol Oncol, Stanford, CA 94305 USA

来源：

BONE | 2019年 / 119卷

基金：

美国国家科学基金会;

关键词：

Erythropoiesis; Macrophage; Erythropoietin; Bone formation; Bone repair; Anemia; Polycythemia; MARROW MACROPHAGES; ERYTHROBLASTIC ISLAND; POLYCYTHEMIA-VERA; FACTOR-I; GROWTH; ANEMIA; CELLS; ANGIOGENESIS; PROTEIN; MURINE;

D O I：

10.1016/j.bone.2018.03.014

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The regulation of erythropoiesis in the bone marrow microenvironment is a carefully orchestrated process that is dependent upon both systemic and local cues. Systemic erythropoietin (EPO) production by renal interstitial cells plays a critical role in maintaining erythropoietic homeostasis. In addition, there is increasing clinical and preclinical data linking changes in EPO and erythropoiesis to altered skeletal homeostasis, suggesting a functional relationship between the regulation of erythropoiesis and bone homeostasis. As key local components of the bone marrow microenvironment and erythropoietic niche, macrophage subsets play important roles in both processes. In this review, we summarize our current understanding of the cellular and molecular mechanisms that may facilitate the coordinated regulation of erythropoiesis and bone homeostasis. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：36 / 41

页数：6

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