Reagentless detection of DNA sequences on chemically modified electrodes

被引：24

作者：

Thorp, HH ^{[1
]}

机构：

[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2003年 / 21卷 / 12期

关键词：

D O I：

10.1016/j.tibtech.2003.10.003

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Microarray analysis requires complex optical instruments and numerous reagents. Several new electrochemical methods for creating sequence-selective microlocations are emerging; such approaches potentially facilitate electrochemical (electronic) readouts of microarrays. These developments parallel the migration of glucose sensing in diabetes monitoring from optical to electrochemical methods. Recent work provides a strategy that minimizes the use of added reagents and potentially produces a reusable sensor that can be applied to continuous monitoring applications.

引用

页码：522 / 524

页数：3

共 22 条

[1] Modification of indium tin oxide electrodes with nucleic acids: Detection of attomole quantities of immobilized DNA by electrocatalysis [J].