Vault-related resistance to anticancer drugs determined by the expression of the major vault protein LRP

被引：17

作者：

Izquierdo, MA

Scheffer, GL

Schroeijers, AB

de Jong, MC

Scheper, RJ

机构：

[1] Free Univ Amsterdam Hosp, Dept Pathol, NL-1081 HV Amsterdam, Netherlands

[2] Catalan Inst Oncol, Dept Med Oncol, Barcelona 08907, Spain

来源：

CYTOTECHNOLOGY | 1998年 / 27卷 / 1-3期

关键词：

drug resistance; lung resistance-related protein; multidrug resistance; multidrug resistance protein; P-glycoprotein; vaults;

D O I：

10.1023/A:1008004502861

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In this review we analyze the data supporting the notion that vault-related MDR, as reflected by LRP/MVP overexpression, represents a marker of drug resistance in vitro and in the clinic. Vaults, besides playing a fundamental biological role, may be involved in a novel mechanism of MDR.

引用

页码：137 / 148

页数：12

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