Clopidogrel resistance - More grist for the mill

被引：15

作者：

Cairns, John A. ^{[1
]}

Eikelboom, John ^{[2
]}

机构：

[1] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada

[2] McMaster Univ, Hamilton, ON, Canada

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2008年 / 51卷 / 20期

关键词：

D O I：

10.1016/j.jacc.2008.01.051

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Clopidogrel has similar efficacy as aspirin for the prevention of thrombotic vascular events among patients with atherosclerotic vascular disease (1) and is a suitable alternative for those with aspirin intolerance or allergy. When added to aspirin, clopidogrel reduces the incidence of thrombotic vascular outcomes among patients with acute coronary syndromes (2-4) and those undergoing percutaneous coronary intervention (PCI) (5-7). Given the wide prevalence of atherosclerotic vascular diseases and the high event rates, efforts are widespread to improve upon the therapeutic effectiveness of clopidogrel. The observation that many patients have less than expected platelet inhibition with clopidogrel has given rise to the concept of clopidogrel resistance and research to identify and overcome the phenomenon (8).

引用

页码：1935 / 1937

页数：3

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