Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation

被引：241

作者：

Shroyer, NF

Wallis, D

Venken, KJT

Bellen, HJ

Zoghbi, HY ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA

[4] Baylor Coll Med, Howard Hughes Med Inst, Houston, TX 77030 USA

[5] Baylor Coll Med, Program Dev Biol, Houston, TX 77030 USA

来源：

GENES & DEVELOPMENT | 2005年 / 19卷 / 20期

关键词：

intestinal mucosa; developmental gene expression regulation; cell differentiation; Paneth cell; goblet cell; enteroendocrine cell;

D O I：

10.1101/gad.1353905

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Gfi1 is a transcriptional repressor implicated in lymphomagenesis, neutropenia, and hematopoietic development, as well as ear and lung development. Here, we demonstrate that Gfi1 functions downstream of Math1 in intestinal secretory lineage differentiation. Gfi1(-/-) mice lack Paneth cells, have fewer goblet cells, and supernumerary enteroendocrine cells. Gfi1(-/-) mice show gene expression changes consistent with this altered cell allocation. These data suggest that Gfi1 functions to select goblet/Paneth versus enteroendocrine progenitors. We propose a model of intestinal cell fate choice in which beta-catenin and Cdx function upstream of Math1, and lineage-specific genes such as Ngn3 act downstream of Gfi1.

引用

页码：2412 / 2417

页数：6

共 29 条

[1] A MAMMALIAN HELIX-LOOP-HELIX FACTOR STRUCTURALLY RELATED TO THE PRODUCT OF DROSOPHILA PRONEURAL GENE ATONAL IS A POSITIVE TRANSCRIPTIONAL REGULATOR EXPRESSED IN THE DEVELOPING NERVOUS-SYSTEM [J].