Programmed cell removal: a new obstacle in the road to developing cancer

被引：194

作者：

Chao, Mark P. ^{[1
,2
]}

Majeti, Ravindra ^{[1
,2
,3
]}

Weissman, Irving L. ^{[1
,2
]}

机构：

[1] Stanford Univ, Sch Med, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Inst Canc, Div Haematol, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Div Haematol, Dept Internal Med, Stanford, CA 94305 USA

来源：

NATURE REVIEWS CANCER | 2012年 / 12卷 / 01期

关键词：

UNFOLDED PROTEIN RESPONSE; RECEPTOR-RELATED PROTEIN; ANTIGEN DOWN-REGULATION; MANNOSE-BINDING LECTIN; ACUTE MYELOID-LEUKEMIA; FIND-ME SIGNAL; APOPTOTIC CELLS; TUMOR-CELLS; PROGNOSTIC-FACTOR; STEM-CELLS;

D O I：

10.1038/nrc3171

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The development of cancer involves mechanisms by which aberrant cells overcome normal regulatory pathways that limit their numbers and their migration. The evasion of programmed cell death is one of several key early events that need to be overcome in the progression from normal cellular homeostasis to malignant transformation. Recently, we provided evidence in mouse and human cancers that successful cancer clones must also overcome programmed cell removal. In this Opinion article, we explore the role of programmed cell removal in both normal and neoplastic cells, and we place this pathway in the context of the initiation of programmed cell death.

引用

收藏

页码：58 / 67

页数：11

相关论文

共 142 条

[1]

[Anonymous], UCSD NATURE MOL PAGE

[2] Hox genes in hematopoiesis and leukemogenesis [J].

Argiropoulos, B. ;

Humphries, R. K. .

ONCOGENE, 2007, 26 (47) :6766-6776

[3] Annexin I is an endogenous ligand that mediates apoptotic cell engulfment [J].

Arur, S ;

Uche, UE ;

Rezaul, K ;

Fong, M ;

Scranton, V ;

Cowan, AE ;

Mohler, W ;

Han, DK .

DEVELOPMENTAL CELL, 2003, 4 (04) :587-598

[4] Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis [J].

Bajou, Khalid ;

Peng, Hongjun ;

Laug, Walter E. ;

Maillard, Catherine ;

Noel, Agnes ;

Foidart, Jean M. ;

Martial, Joseph A. ;

DeClerck, Yves A. .

CANCER CELL, 2008, 14 (04) :324-334

[5] CD200 and membrane protein E interactions in the control of myeloid cells [J].

Barclay, AN ;

Wright, GJ ;

Brooke, G ;

Brown, MH .

TRENDS IN IMMUNOLOGY, 2002, 23 (06) :285-290

[6] CD47 (integrin-associated protein) engagement of dendritic cell and macrophage counterreceptors is required to prevent the clearance of donor lymphohematopoietic cells [J].

Blazar, BR ;

Lindberg, FP ;

Ingulli, E ;

Panoskaltsis-Mortari, A ;

Oldenborg, PA ;

Iizuka, K ;

Yokoyama, WM ;

Taylor, PA .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (04) :541-549

[7] Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin [J].

Bournazou, Irini ;

Pound, John D. ;

Duffin, Rodger ;

Bournazos, Stylianos ;

Melville, Lynsey A. ;

Brown, Simon B. ;

Rossi, Adriano G. ;

Gregory, Christopher D. .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (01) :20-32

[8] Integrin-associated protein (CD47) and its ligands [J].

Brown, EJ ;

Frazier, WA .

TRENDS IN CELL BIOLOGY, 2001, 11 (03) :130-135

[9] Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment [J].

Brown, S ;

Heinisch, I ;

Ross, E ;

Shaw, K ;

Buckley, CD ;

Savill, J .

NATURE, 2002, 418 (6894) :200-203

[10] CD200/OX2, a cell surface molecule with immuno-regulatory function, is consistently expressed on hairy cell leukaemia neoplastic cells [J].

Brunetti, Lorenzo ;

Di Noto, Rosa ;

Abate, Giovanna ;

Gorrese, Marisa ;

Gravetti, Angela ;

Raia, Maddalena ;

Scalia, Giulia ;

Pascariello, Caterina ;

Camera, Andrea ;

Del Vecchio, Luigi .

BRITISH JOURNAL OF HAEMATOLOGY, 2009, 145 (05) :665-667

← 1 2 3 4 5 6 7 8 9 10 →