Chromaffin cells: the peripheral brain

被引:29
作者
Bornstein, S. R. [1 ]
Ehrhart-Bornstein, M. [1 ]
Androutsellis-Theotokis, A. [1 ,2 ]
Eisenhofer, G. [1 ]
Vukicevic, V. [1 ]
Licinio, J. [3 ]
Wong, M. L. [3 ]
Calissano, P.
Nistico, G. [2 ]
Preziosi, P. [2 ,4 ]
Levi-Montalcini, R. [2 ]
机构
[1] Univ Dresden, Dept Med 3, Dresden, Germany
[2] European Brain Res Inst Rome, Rome, Italy
[3] John Curtin Med Sch Canberra, Canberra, ACT, Australia
[4] Catholic Univ, Rome, Italy
关键词
adrenal medulla; neurobiology; neuronal differentiation; stem cells; NERVE-GROWTH-FACTOR; NEURAL STEM-CELLS; PC12; CELLS; ADRENAL-GLAND; NEUROTROPHIC FACTOR; PARKINSONS-DISEASE; IN-VIVO; NEURONS; GENE; ACTIVATION;
D O I
10.1038/mp.2011.176
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Chromaffin cells probably are the most intensively studied of the neural crest derivates. They are closely related to the nervous system, share with neurons some fundamental mechanisms and thus were the ideal model to study the basic mechanisms of neurobiology for many years. The lessons we have learned from chromaffin cell biology as a peripheral model for the brain and brain diseases pertain more than ever to the cutting edge research in neurobiology. Here, we highlight how studying this cell model can help unravel the basic mechanisms of cell renewal and regeneration both in the central nervous system (CNS) and neuroendocrine tissue and also can help in designing new strategies for regenerative therapies of the CNS. Molecular Psychiatry ( 2012) 17, 354-358; doi: 10.1038/mp.2011.176; published online 17 January 2012
引用
收藏
页码:354 / 358
页数:5
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