Finding drug targets in microbial genomes

被引：24

作者：

Read, TD

Gill, SR

Tettelin, H

Dougherty, BA

机构：

[1] Inst Genom Res, Microbial Genom Grp, Rockville, MD 20851 USA

[2] Bristol Myers Squibb Co, Pharmaceut Res Inst, Wallingford, CT 06492 USA

来源：

DRUG DISCOVERY TODAY | 2001年 / 6卷 / 17期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1359-6446(01)01914-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this era of genomic science, knowledge about biological function is integrated increasingly with DNA sequence data. One area that has been significantly impacted by this accumulation of information is the discovery of drugs to treat microbial infections. Genome sequencing and bioinformatics is driving the discovery and development of novel classes of broad-spectrum antimicrobial compounds, and could enable medical science to keep pace with the increasing resistance of bacteria, fungi and parasites to current antimicrobials. This review discusses the use of genomic information in the rapid identification of target genes for antimicrobial drug discovery.

引用

收藏

页码：887 / 892

页数：6

相关论文

共 52 条

[1] Bacterial virulence as a target for antimicrobial chemotherapy [J].

Alksne, LE ;

Projan, SJ .

CURRENT OPINION IN BIOTECHNOLOGY, 2000, 11 (06) :625-636

[2] Identification and analysis of bacterial protein secretion inhibitors utilizing a SecA-LacZ reporter fusion system [J].

Alksne, LE ;

Burgio, P ;

Hu, W ;

Feld, B ;

Singh, MP ;

Tuckman, M ;

Petersen, PJ ;

Labthavikul, P ;

McGlynn, M ;

Barbieri, L ;

McDonald, L ;

Bradford, P ;

Dushin, RG ;

Rothstein, D ;

Projan, SJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (06) :1418-1427

[3] New antibiotic discovery, novel screens, novel targets and impact of microbial genomics [J].

Allsop, AE .

CURRENT OPINION IN MICROBIOLOGY, 1998, 1 (05) :530-534

[4] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].

Altschul, SF ;

Madden, TL ;

Schaffer, AA ;

Zhang, JH ;

Zhang, Z ;

Miller, W ;

Lipman, DJ .

NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402

[5] Iterated profile searches with PSI-BLAST - a tool for discovery in protein databases [J].

Altschul, SF ;

Koonin, EV .

TRENDS IN BIOCHEMICAL SCIENCES, 1998, 23 (11) :444-447

[6] The genome sequence of Rickettsia prowazekii and the origin of mitochondria [J].

Andersson, SGE ;

Zomorodipour, A ;

Andersson, JO ;

Sicheritz-Pontén, T ;

Alsmark, UCM ;

Podowski, RM ;

Näslund, AK ;

Eriksson, AS ;

Winkler, HH ;

Kurland, CG .

NATURE, 1998, 396 (6707) :133-140

[7] Pfam 3.1: 1313 multiple alignments and profile HMMs match the majority of proteins [J].

Bateman, A ;

Birney, E ;

Durbin, R ;

Eddy, SR ;

Finn, RD ;

Sonnhammer, ELL .

NUCLEIC ACIDS RESEARCH, 1999, 27 (01) :260-262

[8] Comparative genomics of BCG vaccines by whole-genome DNA microarray [J].

Behr, MA ;

Wilson, MA ;

Gill, WP ;

Salamon, H ;

Schoolnik, GK ;

Rane, S ;

Small, PM .

SCIENCE, 1999, 284 (5419) :1520-1523

[9] The complete genome sequence of Escherichia coli K-12 [J].

Blattner, FR ;

Plunkett, G ;

Bloch, CA ;

Perna, NT ;

Burland, V ;

Riley, M ;

ColladoVides, J ;

Glasner, JD ;

Rode, CK ;

Mayhew, GF ;

Gregor, J ;

Davis, NW ;

Kirkpatrick, HA ;

Goeden, MA ;

Rose, DJ ;

Mau, B ;

Shao, Y .

SCIENCE, 1997, 277 (5331) :1453-+

[10] Exploring the new world of the genome with DNA microarrays [J].

Brown, PO ;

Botstein, D .

NATURE GENETICS, 1999, 21 (Suppl 1) :33-37

← 1 2 3 4 5 6 →