A scanning tunneling microscopy study of rabbit metallothionein

被引：22

作者：

Davis, J. J. ^{[1
]}

Hill, H. Allen O. ^{[1
]}

Kurz, Arnd ^{[1
]}

Jacob, Claus ^{[2
]}

Maret, Wolfgang ^{[2
]}

Vallee, Bert L. ^{[2
]}

机构：

[1] New Chem Lab, Oxford OX1 3QT, England

[2] Harvard Univ, Sch Med, Ctr Biochem & Biophys Sci & Med, Boston, MA 02115 USA

来源：

PHYSCHEMCOMM | 1998年 / 1卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1039/a806057f

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The application of scanning probe methods to the high-resolution imaging of biological structure has been developing rapidly during the past few years. In contrast to diffraction and electron microscopy methods, imaging is direct and can be carried out under fluid. Scanning Tunneling Microscopy (STM) allows a resolution of electronic as well as topographic structure, and we are accordingly interested in its application to the high resolution imaging of metalloproteins. Metallothionein has been imaged under buffered solution by in situ STM. The dumbbell morphology has been resolved and the metal centers appear to give rise to enhanced tunneling current.

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页数：11

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