Recent advances in fetal nucleic acids in maternal plasma

被引:42
作者
Lo, YMD [1 ]
机构
[1] Chinese Univ Hong Kong, Dept Chem Pathol, Prince Wales Hosp, Hong Kong, Hong Kong, Peoples R China
关键词
noninvasive prenatal diagnosis; plasma DNA; plasma RNA;
D O I
10.1369/jhc.4R6362.2005
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The discovery of cell-free fetal DNA in maternal plasma in 1997 has opened up new possibilities for noninvasive prenatal diagnosis. Circulating fetal DNA molecules have been detected in maternal plasma from the first trimester onwards and can be robustly detected using a variety of molecular methods. This approach has been used for the prenatal investigation of sex-linked diseases, fetal RhD status, and prenatal exclusion of beta-thalassemia major. Recently, fetal RNA has also been found in maternal plasma. Such fetal RNA has been shown to originate from the placenta and to be remarkably stable. The use of microarray-based approaches has made it feasible to rapidly generate new circulating RNA markers. It is hoped that further developments in this field will make the routine and widespread practice of noninvasive nucleic acid-based prenatal diagnosis for common pregnancy-associated disorders feasible in the near future.
引用
收藏
页码:293 / 296
页数:4
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