giant nuclei is essential in the cell cycle transition from meiosis to mitosis

被引：27

作者：

Renault, AD

Zhang, XH

Alphey, LS

Frenz, LM

Glover, DM

Saunders, RDC

Axton, JM

机构：

[1] Univ Oxford, Dept Zool, Oxford OX1 3PS, England

[2] Babraham Inst, Babraham Bioincubator 405, Polgen Div, Cambridge CB2 4AT, England

[3] Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England

[4] Open Univ, Dept Biol Sci, Milton Keynes MK7 6AA, Bucks, England

来源：

DEVELOPMENT | 2003年 / 130卷 / 13期

关键词：

Drosophila melanogaster; mitosis; DNA replication; fertilization; oogenesis; protein phosphatase 1;

D O I：

10.1242/dev.00501

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

At the transition from meiosis to cleavage mitoses, Drosophila requires the cell cycle regulators encoded by the genes, giant nuclei (gnu),plutonium (plu) and pan gu (png). Embryos lacking Gnu protein undergo DNA replication and centrosome proliferation without chromosome condensation or mitotic segregation. We have identified the gnu gene encoding a novel phosphoprotein dephosphorylated by Protein phosphatase 1 at egg activation. Gnu is normally expressed in the nurse cells and oocyte of the ovary and is degraded during the embryonic cleavage mitoses. Ovarian death and sterility result from gnu gain of function. gnu function requires the activity of pan gu and plu.

引用

页码：2997 / 3005

页数：9

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