Body composition and androgen pattern in the early period of postmenopause

被引:11
作者
De Lorenzo, A [1 ]
Lello, S [1 ]
Andreoli, A [1 ]
Guardianelli, F [1 ]
Romanini, C [1 ]
机构
[1] Univ Roma Tor Vergata, Dipartimento Med Sperimentale, Dept Human Physiol, I-00173 Rome, Italy
关键词
body composition; DXA; BMD; androgens; postmenopause;
D O I
10.3109/09513599809015541
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Body composition is related to age, genetic factors, and hormonal patterns throughout life. Peak bone mass seems to be an important protective factor against osteoporosis, although diet and life-style (smoking, physical activity) are able to influence bone mass. While it is well known that estrogens exert a protective action against bone loss in postmenopausal women, the role of androgens is still not clear. Twenty-five women in the early postmenopausal period (age: 52.8 +/- 5.1 years) were measured by dual-energy x-ray absorptiometry (DXA) to assess the relationship between body composition (fat mass and lean mass), bone mineral content (BMC), bone mineral density (BMD) and androgen pattern. Waist/hip ratio was used to divide the study population in three groups: gynecoid (gluteo-femural fat distribution), android (abdominal fat distribution), and intermediate. In all subjects an inverse significant correlation between estradiol and fat mass was found. In the abdominal fat distribution group significant correlations between estradiol and weight (inversely correlated), androstenedione and BMD, lean mass and BMC were found. The data show the important role of androgens (androstenedione, particularly) and lean body mass on the BMD and BMC, respectively, in the early period of postmenopause.
引用
收藏
页码:171 / 177
页数:7
相关论文
共 41 条
[1]  
ADASHI EY, 1994, FERTIL STERIL, V62, P20
[2]  
AZZIZ R, 1989, FERTIL STERIL, V52, P703
[3]  
BARBIERI RL, 1988, FERTIL STERIL, V50, P197
[4]   BODY-COMPOSITION - PREDICTION OF NORMAL BODY POTASSIUM, BODY-WATER AND BODY-FAT IN ADULTS ON THE BASIS OF BODY HEIGHT, BODY-WEIGHT AND AGE [J].
BRUCE, A ;
ANDERSSON, M ;
ARVIDSSON, B ;
ISAKSSON, B .
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1980, 40 (05) :461-473
[5]   EFFECT OF EXCESS ENDOGENOUS ANDROGENS ON BONE-DENSITY IN YOUNG-WOMEN [J].
BUCHANAN, JR ;
HOSPODAR, P ;
MYERS, C ;
LEUENBERGER, P ;
DEMERS, LM .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1988, 67 (05) :937-943
[6]   SHORT-TERM EFFECTS OF SMOKING ON THE PHARMACOKINETIC PROFILES OF MICRONIZED ESTRADIOL IN POSTMENOPAUSAL WOMEN [J].
CASSIDENTI, DL ;
VIJOD, AG ;
VIJOD, MA ;
STANCZYK, FZ ;
LOBO, RA .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1990, 163 (06) :1953-1960
[7]   THE SENSITIVITY OF ISOLATED OSTEOCLASTS TO MORPHOLOGICAL TRANSFORMATION BY CALCITONIN [J].
CHAMBERS, TJ ;
MOORE, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1983, 57 (04) :819-824
[8]  
CHESNUT CH, 1983, METABOLISM, V32, P577
[9]   IDENTIFICATION OF ANDROGEN RECEPTORS IN NORMAL HUMAN OSTEOBLAST-LIKE CELLS [J].
COLVARD, DS ;
ERIKSEN, EF ;
KEETING, PE ;
WILSON, EM ;
LUBAHN, DB ;
FRENCH, FS ;
RIGGS, BL ;
SPELSBERG, TC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (03) :854-857
[10]   Within-subject variability in body composition using dual-energy X-ray absorptiometry [J].
DeLorenzo, A ;
Andreoli, A ;
Candeloro, N .
CLINICAL PHYSIOLOGY, 1997, 17 (04) :383-388