Seroprevalence of neutralizing antibodies to adenovirus type 5 among children in India: Implications for recombinant adenovirus-based Vaccines

被引：28

作者：

Appaiahgari, Mohan Babu

Pandey, Ravindra Mohan

Vrati, Sudhanshu

机构：

[1] Natl Inst Immunol, JNU Complex, New Delhi 110067, India

[2] All India Inst Med Sci, Dept Biostat, New Delhi 110016, India

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2007年 / 14卷 / 08期

关键词：

D O I：

10.1128/CVI.00173-07

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We determined the levels of adenovirus 5 (Ad5) neutralizing antibodies in children in India less than 2 years of age. The results clearly show an age-dependent increase in Ad5-specitic immunity, with 7- to 12-month-old children having the lowest levels of Ad5 immunity. This opens up the scope for the use of recombinant Ad5-based vaccines in this age group.

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页码：1053 / 1055

页数：3

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