Cobalt(II)-catalyzed cross-coupling of polyfunctional aryl copper reagents with aryl bromides and chlorides

被引:79
作者
Korn, TJ [1 ]
Knochel, P [1 ]
机构
[1] Univ Munich, Dept Chem, D-81377 Munich, Germany
关键词
cobalt; cross-coupling; Grignard reagents; heterocycles; organocopper compounds;
D O I
10.1002/anie.200500099
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
(Chemical Equation Presented) Polyfunctionalized biphenyl and heteroaromatic compounds were formed in the presence of [Co(acac)2], Bu4Nl, and 4-fluorostyrene (3) through a smooth cross-coupling reaction between organocopper reagents 1, prepared by the transmetalation of functionalized aryl magnesium halides with CuCN·2 LiCl, and aryl halides 2 that bear electron-withdrawing substituents. acac = acetylacetonate, DME = 1,2-dimethoxyethane, DMPU = 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone. © 2005 Wilex-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:2947 / 2951
页数:5
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