β-Lactamases:: Protein evolution in real time

被引：82

作者：

Petrosino, J ^{[1
]}

Cantu, C

Palzkill, T

机构：

[1] Baylor Coll Med, Dept Microbiol & Immunol, Houston, TX 77030 USA

[2] Baylor Coll Med, Program Struct & Computat Biol & Mol Biophys, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Biochem, Houston, TX 77030 USA

来源：

TRENDS IN MICROBIOLOGY | 1998年 / 6卷 / 08期

关键词：

D O I：

10.1016/S0966-842X(98)01317-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The evolution and spread of bacteria resistant to beta-lactam antibiotics has progressed at an alarming rate. Bacteria may acquire resistance to a given drug by mutation of pre-existing genes or by the acquisition of new genes from other bacteria. One ongoing example of these mechanisms is the evolution of new variants of the TEM and SHV beta-lactamases with altered substrate specificity.

引用

页码：323 / 327

页数：5

共 45 条

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