Effect of atorvastatin 80 mg on endothelial cell function (forearm blood flow) in patients with pretreatment serum low-density lipoprotein cholesterol levels <130 mg/dl

被引:42
作者
Wassmann, S [1 ]
Ribaudo, N [1 ]
Faul, A [1 ]
Laufs, U [1 ]
Böhm, M [1 ]
Nickenig, G [1 ]
机构
[1] Univ Saarlandes Kliniken, Med Klin & Poliklin, Homburg, Germany
关键词
D O I
10.1016/j.amjcard.2003.09.018
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The effect of 6-week treatment with 80 mg/day atorvastatin on vascular function in the forearm was investigated in 1.8 patients with mean. pretreatment serum low-density lipoprotein cholesterol concentrations of 112 +/- 4 mg/dl in a double-blind, placebo-controlled, randomized study. Statin treatment improved hyperemic forearm blood flow and decreased serum markers of oxidative stress and inflammation. (C) 2003 by Excerpta Medica, Inc.
引用
收藏
页码:84 / 88
页数:5
相关论文
共 15 条
[1]   THE EFFECT OF CHOLESTEROL-LOWERING AND ANTIOXIDANT THERAPY ON ENDOTHELIUM-DEPENDENT CORONARY VASOMOTION [J].
ANDERSON, TJ ;
MEREDITH, IT ;
YEUNG, AC ;
FREI, B ;
SELWYN, AP ;
GANZ, P .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (08) :488-493
[2]   Novel clinical markers of vascular wall inflammation [J].
Blake, GJ ;
Ridker, PM .
CIRCULATION RESEARCH, 2001, 89 (09) :763-771
[3]   Endothelial dysfunction in cardiovascular diseases - The role of oxidant stress [J].
Cai, H ;
Harrison, DG .
CIRCULATION RESEARCH, 2000, 87 (10) :840-844
[4]  
Collins R, 2002, LANCET, V360, P7, DOI 10.1016/S0140-6736(02)09327-3
[5]   Calf and forearm blood flow in hypercholesterolemic patients [J].
Cortella, A ;
Zambon, S ;
Sartore, G ;
Piarulli, F ;
Calabrò, A ;
Manzato, E ;
Crepaldi, G .
ANGIOLOGY, 2000, 51 (04) :309-318
[6]   REDUCTION IN SERUM-CHOLESTEROL WITH PRAVASTATIN IMPROVES ENDOTHELIUM-DEPENDENT CORONARY VASOMOTION IN PATIENTS WITH HYPERCHOLESTEROLEMIA [J].
EGASHIRA, K ;
HIROOKA, Y ;
KAI, H ;
SUGIMACHI, M ;
SUZUKI, S ;
INOU, T ;
TAKESHITA, A .
CIRCULATION, 1994, 89 (06) :2519-2524
[7]   Effect of estrogen replacement therapy on endothelial function in peripheral resistance arteries in normotensive and hypertensive postmenopausal women [J].
Higashi, Y ;
Sanada, M ;
Sasaki, S ;
Nakagawa, K ;
Goto, C ;
Matsuura, H ;
Ohama, K ;
Chayama, K ;
Oshima, T .
HYPERTENSION, 2001, 37 (02) :651-657
[8]   Vascular effects of HMG CoA-reductase inhibitors (statins) unrelated to cholesterol lowering: new concepts for cardiovascular disease [J].
Lefer, AM ;
Scalia, R ;
Lefer, DJ .
CARDIOVASCULAR RESEARCH, 2001, 49 (02) :281-287
[9]  
Mullen MJ, 2001, CIRC RES, V88, P145
[10]  
Ridker P M, 2000, Adv Intern Med, V45, P391