IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel

被引：1702

作者：

Lennon, VA ^{[1
]}

Kryzer, TJ

Pittock, SJ

Verkman, AS

Hinson, SR

机构：

[1] Mayo Clin, Coll Med, Dept Immunol, Rochester, MN 55905 USA

[2] Mayo Clin, Coll Med, Dept Neurol, Rochester, MN 55905 USA

[3] Mayo Clin, Coll Med, Dept Lab Med & Pathol, Rochester, MN 55905 USA

[4] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2005年 / 202卷 / 04期

关键词：

D O I：

10.1084/jem.20050304

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that selectively affects optic nerves and spinal cord. It is considered a severe variant of multiple sclerosis (MS), and frequently is misdiagnosed as MS, but prognosis and optimal treatments differ. A serum immunoglobulin G autoantibody (NMO-IgG) serves as a specific marker for NMO. Here we show that NMO-IgG binds selectively to the aquaporin-4 water channel, a component of the dystroglycan protein complex located in astrocytic foot processes at the blood-brain barrier. NMO may represent the first example of a novel class of autoimmune channelopathy.

引用

页码：473 / 477

页数：5

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