SR 141716A, a cannabinoid receptor antagonist, produces hyperalgesia in untreated mice

被引：121

作者：

Richardson, JD

Aanonsen, L

Hargreaves, KM

机构：

[1] UNIV MINNESOTA,DEPT RESTORAT SCI,MINNEAPOLIS,MN 55455

[2] MACALESTER COLL,DEPT BIOL,ST PAUL,MN 55105

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1997年 / 319卷 / 2-3期

关键词：

cannabinoid; hyperalgesia; pain;

D O I：

10.1016/S0014-2999(96)00952-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Antinociceptive effects of cannabinoids are well documented. However, the physiological role of endogenous cannabinoids in nociception is unknown. We evaluated the effects of the cannabinoid receptor antagonist SR 141716A (N-piperidino-5-(4-chlorophenyl)1-(2,4-dichlorophenyl)-4-methyl- 3-pyrazolecarboxamide) on mouse hot plate latencies. Intrathecal injection of SR 141716A evoked a significant thermal hyperalgesia. These results suggest that the cannabinoid system tonically regulates thermal nociceptive thresholds. Furthermore, the absence of this regulation results in hyperalgesia suggesting that hypoactivity of this system may be involved in certain types of chronic pain.

引用

页码：R3 / R4

页数：2

共 8 条

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