Dark Agouti rat model of chemotherapy-induced mucositis: Establishment and current state of the art

被引：28

作者：

Vanhoecke, Barbara ^{[1
,2
]}

Bateman, Emma ^{[1
]}

Mayo, Bronwen ^{[1
,3
]}

Vanlancker, Eline ^{[2
]}

Stringer, Andrea ^{[3
]}

Thorpe, Daniel ^{[3
]}

Keefe, Dorothy ^{[1
,4
]}

机构：

[1] Univ Adelaide, Oral Hlth, Fac Hlth Sci, CCRE,CPCM,Mucositis Res Grp, Adelaide, SA 5005, Australia

[2] Univ Ghent, Lab Microbial Ecol & Technol, B-9000 Ghent, Belgium

[3] Univ S Australia, Sansom Inst Hlth Res, Adelaide, SA 5001, Australia

[4] Royal Adelaide Hosp, SA Canc Serv, Adelaide, SA 5005, Australia

来源：

EXPERIMENTAL BIOLOGY AND MEDICINE | 2015年 / 240卷 / 06期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

Rat; mucositis; methotrexate; 5-fluorouracil; irinotecan; chemotherapy; PLATELET-ACTIVATING-FACTOR; INTESTINAL TREFOIL FACTOR; EPIDERMAL-GROWTH-FACTOR; MURINE GASTROINTESTINAL MUCOSA; METHOTREXATE-INDUCED DAMAGE; ALIMENTARY-TRACT MUCOSITIS; INDUCED GASTRIC INJURY; NF-KAPPA-B; INDUCED APOPTOSIS; GENE-EXPRESSION;

D O I：

10.1177/1535370215581309

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Mucositis is a major oncological problem. The entire gastrointestinal and genitourinary tract and also other mucosal surfaces can be affected in recipients of radiotherapy, and/or chemotherapy. Major progress has been made in recent years in understanding the mechanisms of oral and small intestinal mucositis, which appears to be more prominent than colonic damage. This progress is largely due to the development of representative laboratory animal models of mucositis. This review focuses on the development and establishment of the Dark Agouti rat mammary adenocarcinoma model by the Mucositis Research Group of the University of Adelaide over the past 20 years to characterize the mechanisms underlying methotrexate- ,5-fluorouracil-, and irinotecan-induced mucositis. It also aims to summarize the results from studies using different animal model systems to identify new molecular and cellular markers of mucositis.

引用

页码：725 / 741

页数：17

共 150 条

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