The enantioselective, Bronsted acid catalyzed, vinylogous Mannich reaction

被引：147

作者：

Sickert, Marcel ^{[1
]}

Schneider, Christoph ^{[1
]}

机构：

[1] Univ Leipzig, Inst Organ Chem, D-04103 Leipzig, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 19期

关键词：

asymmetric catalysis; C-C coupling; contact ion pairs; organocatalysis; phosphoric acid;

D O I：

10.1002/anie.200800103

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Chiral phosphoric acid 4 catalyzes enantioselectively the highly γ-regioselective addition of a silyl dienolate 2 to imines 1 in good yields and furnishes α,β-unsaturated δ-amino carboxylic esters 3 in one step. The reaction may also be carried out as a direct three-component coupling (PMP = para-methoxyphenyl; TBS = tertbutyldimethylsilyl). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3631 / 3634

页数：4

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