NGAL (neutrophil gelatinase-associated lipocalin) and cystatin C: Are they good predictors of contrast nephropathy after percutaneous coronary interventions in patients with stable angina and normal serum creatinine?

被引：58

作者：

Bachorzewska-Gajewska, H. ^{[2
]}

Malyszko, J. ^{[1
,2
]}

Sitniewska, E. ^{[2
]}

Malyszko, J. S. ^{[2
]}

Poniatowski, B. ^{[2
]}

Pawlak, K. ^{[2
]}

Dobrzycki, S. ^{[2
]}

机构：

[1] Med Univ, Dept Nephrol & Transplantol, PL-15540 Bialystok, Poland

[2] Med Univ, Dept Invas Cardiol, PL-15540 Bialystok, Poland

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2008年 / 127卷 / 02期

关键词：

contrast nephropathy; NGAL; cystatin C; coronary artery disease; PCI;

D O I：

10.1016/j.ijcard.2007.04.048

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of the study was to assess whether NGAL and cystatin C could predict contrast-induced nephropathy in non-diabetic patients (n = 60, mean age 60 +/- 11 years) with normal serum creatinine undergoing elective PCI. We found a significant rise in serum NGAL after 2, 4 and 8 h, and in urinary NGAL after 4, 8 and 24 h after PCI. Cystatin C rose significantly 8 and 24 h after the procedure. Prevalence of CIN was 10%. We found 90% sensitivity and 74% specificity of serum and 76% sensitivity and 80% specificity of urinary NGAL increase. NGAL may represent a sensitive early biomarkers of renal impairment after PCI. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：290 / 291

页数：2

共 9 条

[1] Defining acute renal failure: physiological principles [J].

Bellomo, R ;

Kellum, JA ;

Ronco, C .

INTENSIVE CARE MEDICINE, 2004, 30 (01) :33-37

[2] Contrast nephropathy after coronary angiography [J].

Gami, AS ;

Garovic, VD .

MAYO CLINIC PROCEEDINGS, 2004, 79 (02) :211-219

[3] Expression of neutrophil gelatinase-associated lipocalin in atherosclerosis and myocardial infarction [J].

Hemdahl, AL ;

Gabrielsen, A ;

Zhu, CY ;

Eriksson, P ;

Hedin, U ;

Kastrup, J ;

Thorén, P ;

Hansson, GK .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2006, 26 (01) :136-142

[4] Early detection of acute renal failure by serum cystatin C [J].

Herget-Rosenthal, S ;

Marggraf, G ;

Hüsing, J ;

Göring, F ;

Pietruck, F ;

Janssen, O ;

Philipp, T ;

Kribben, A .

KIDNEY INTERNATIONAL, 2004, 66 (03) :1115-1122

[5] Contrast-induced nephropathy in patients undergoing primary angioplasty for acute myocardial infarction [J].

Marenzi, G ;

Lauri, G ;

Assanelli, E ;

Campodonico, J ;

De Metrio, M ;

Marana, I ;

Grazi, M ;

Veglia, F ;

Bartorelli, AL .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 44 (09) :1780-1785

[6]

Mishra Jaya, 2005, Lancet, V365, P1231, DOI 10.1016/S0140-6736(05)74811-X

[7] Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery [J].

Parikh, C. R. ;

Mishra, J. ;

Thiessen-Philbrook, H. ;

Dursun, B. ;

Ma, Q. ;

Kelly, C. ;

Dent, C. ;

Devarajan, P. ;

Edelstein, C. L. .

KIDNEY INTERNATIONAL, 2006, 70 (01) :199-203

[8]

Rickli H, 2004, CLIN NEPHROL, V61, P98

[9] Association between increases in urinary neutrophil gelatinase-associated lipocalin and acute renal dysfunction after adult cardiac surgery [J].

Wagener, Gebhard ;

Jan, Michael ;

Kim, Mihwa ;

Mori, Kiyoshi ;

Barasch, Jonathan M. ;

Sladen, Robert N. ;

Lee, H. Thomas .

ANESTHESIOLOGY, 2006, 105 (03) :485-491

← 1 →